AAT68886.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,071 Da
NCBI Official Full Name
defensin, alpha 5, Paneth cell-specific
NCBI Official Synonym Full Names
defensin, alpha 5, Paneth cell-specific
NCBI Official Synonym Symbols
NCBI Protein Information
defensin-5; HD5(20-94); defensin 5; defensin, alpha 5, preproprotein
UniProt Protein Name
Defensin-5
UniProt Synonym Protein Names
Defensin, alpha 5; HD5(20-94)Cleaved into the following 4 chains:HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)
UniProt Synonym Gene Names
UniProt Entry Name
DEF5_HUMAN
NCBI Summary for DEFalpha5
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Jul 2008]
UniProt Comments for DEFalpha5
DEFA5: Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. Belongs to the alpha-defensin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 8p23.1
Cellular Component: extracellular space; transport vesicle; Golgi lumen; extracellular region
Biological Process: killing of cells of another organism; antibacterial humoral response; innate immune response; defense response to fungus
Research Articles on DEFalpha5
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Products associated with DEFalpha5 elisa kit
Pathways associated with DEFalpha5 elisa kit
Diseases associated with DEFalpha5 elisa kit
Organs/Tissues associated with DEFalpha5 elisa kit
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