CAG38812.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
24,423 Da
NCBI Official Full Name
DF
NCBI Official Synonym Full Names
complement factor D (adipsin)
NCBI Protein Information
complement factor D; properdin factor D; C3 convertase activator; complement factor D preproprotein; D component of complement (adipsin)
UniProt Protein Name
DF protein
UniProt Entry Name
Q6FHW3_HUMAN
NCBI Summary for DF
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
UniProt Comments for DF
CFD: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Defects in CFD are the cause of complement factor D deficiency (CFDD). CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway. Belongs to the peptidase S1 family.
Protein type: EC 3.4.21.46; Protease; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: extracellular space; extracellular region
Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: platelet activation; platelet degranulation; complement activation, alternative pathway; innate immune response; blood coagulation; proteolysis; complement activation
Disease: Complement Factor D Deficiency
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Pathways associated with DF elisa kit
Organs/Tissues associated with DF elisa kit
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