NP_001191195.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,623 Da
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit alpha-4 isoform 2
NCBI Official Synonym Full Names
gamma-aminobutyric acid (GABA) A receptor, alpha 4
NCBI Protein Information
gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor, alpha 4; gamma-aminobutyric acid A receptor alpha 4
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit alpha-4
UniProt Synonym Protein Names
GABA(A) receptor subunit alpha-4
UniProt Entry Name
GBRA4_HUMAN
NCBI Summary for gammaABRalpha2
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
UniProt Comments for gammaABRalpha2
GABRA4: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA4 sub-subfamily.
Protein type: Membrane protein, multi-pass; Transporter; Channel, ligand-gated; Channel, chloride; Membrane protein, integral; Transporter, ion channel
Chromosomal Location of Human Ortholog: 4p12
Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction
Molecular Function: chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity
Biological Process: synaptic transmission; central nervous system development; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway
Research Articles on gammaABRalpha2
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Organs/Tissues associated with gammaABRalpha2 elisa kit
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