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HNF4alpha elisa kit :: Monkey Hepatocyte Nuclear Factor 4 Alpha ELISA Kit

Scan QR to view Datasheet Catalog #    MBS040327 HNF4alpha elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Hepatocyte Nuclear Factor 4 Alpha (HNF4alpha), ELISA Kit

 Also Known As   

Monkey Hepatocyte Nuclear Factor 4 Alpha ELISA Kit

 Product Gene Name   

HNF4alpha elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 20; NC_000020.10 (42984441..43061485). Location: 20q13.12
 OMIM    125850
 3D Structure    ModBase 3D Structure for P41235
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of HNF4alpha elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for HNF4alpha purchase    MBS040327 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Hepatocyte Nuclear Factor 4 Alpha (HNF4alpha) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HNF4alpha. The ELISA analytical biochemical technique of the MBS040327 kit is based on HNF4alpha antibody-HNF4alpha antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HNF4alpha antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HNF4alpha. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for HNF4alpha. It may not necessarily be applicable to this product.
 NCBI GI #    31077209
 NCBI GeneID    3172
 NCBI Accession #    NP_849181.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_178850.2 [Other Products]
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 UniProt Primary Accession #    P41235 [Other Products]
 UniProt Secondary Accession #    O00659; O00723; Q14540; Q5QPB8; Q6B4V5; Q6B4V6; Q6B4V7; Q92653; Q92654; A5JW41; B2RPP8 [Other Products]
 UniProt Related Accession #    P41235 [Other Products]
 Molecular Weight    52,785 Da
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 NCBI Official Full Name    hepatocyte nuclear factor 4-alpha isoform c
 NCBI Official Synonym Full Names    hepatocyte nuclear factor 4, alpha
 NCBI Official Symbol    HNF4A [Similar Products]
 NCBI Official Synonym Symbols   
TCF; HNF4; MODY; MODY1; NR2A1; TCF14; HNF4a7; HNF4a8; HNF4a9; NR2A21; HNF4alpha
[Similar Products]
 NCBI Protein Information    hepatocyte nuclear factor 4-alpha; TCF-14; HNF4alpha10/11/12; transcription factor 14; transcription factor HNF-4; hepatic nuclear factor 4 alpha; nuclear receptor subfamily 2 group A member 1
 UniProt Protein Name    Hepatocyte nuclear factor 4-alpha
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 2 group A member 1; Transcription factor 14; TCF-14; Transcription factor HNF-4
 UniProt Gene Name    HNF4A [Similar Products]
 UniProt Synonym Gene Names    HNF4; NR2A1; TCF14; HNF-4-alpha; TCF-14 [Similar Products]
 UniProt Entry Name    HNF4A_HUMAN
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 NCBI Summary for HNF4alpha    The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
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 UniProt Comments for HNF4alpha    HNF4 alpha: a nuclear transcription factor which binds DNA as a homodimer. Controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic gene, alpha 1-antitrypsin, apolipoprotein CIII, and transthyretin genes. May be essential for development of the liver, kidney and intestine. Mutations have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Four alternatively spliced isoforms have been described.

Protein type: Transcription factor; Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; protein homodimerization activity; DNA binding; zinc ion binding; steroid hormone receptor activity; fatty acid binding; transcription factor activity; receptor binding

Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; lipid homeostasis; glucose homeostasis; endocrine pancreas development; regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; xenobiotic metabolic process; regulation of gastrulation; response to glucose stimulus; ornithine metabolic process; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; lipid metabolic process; negative regulation of cell growth; blood coagulation; sex differentiation; regulation of insulin secretion; phospholipid homeostasis

Disease: Fanconi Renotubular Syndrome 4 With Maturity-onset Diabetes Of The Young; Maturity-onset Diabetes Of The Young, Type 1; Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on HNF4alpha    1. investigation of HNF4alpha genetic polymorphisms may improve the predictability of CYP2D6 activity in different populations
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HNF4alpha elisa kitDiseases associated with HNF4alpha elisa kit
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Disease Name  Pubmed Publications
 Diabetes Mellitus, Type 2 Antibodies  >183 publications with HNF4alpha and Diabetes Mellitus, Type 2
 MATURITY-ONSET DIABETES OF THE YOUNG Antibodies  >137 publications with HNF4alpha and MATURITY-ONSET DIABETES OF THE YOUNG
 Liver Diseases Antibodies  >67 publications with HNF4alpha and Liver Diseases
 Neoplasms Antibodies  >66 publications with HNF4alpha and Neoplasms
 Liver Neoplasms Antibodies  >42 publications with HNF4alpha and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >41 publications with HNF4alpha and Carcinoma, Hepatocellular
 Hyperglycemia Antibodies  >34 publications with HNF4alpha and Hyperglycemia
 Fatty Liver Antibodies  >31 publications with HNF4alpha and Fatty Liver
 Insulin Resistance Antibodies  >23 publications with HNF4alpha and Insulin Resistance
 Inflammation Antibodies  >17 publications with HNF4alpha and Inflammation
Organs/Tissues associated with HNF4alpha elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >281 publications with HNF4alpha and Liver
 Kidney Antibodies  >36 publications with HNF4alpha and Kidney
 Intestine Antibodies  >32 publications with HNF4alpha and Intestine
 Stomach Antibodies  >10 publications with HNF4alpha and Stomach
 Lung Antibodies  >5 publications with HNF4alpha and Lung
 Placenta Antibodies  >4 publications with HNF4alpha and Placenta
 Mammary Gland Antibodies  >1 publications with HNF4alpha and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with HNF4alpha and Uncharacterized Tissue
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