NP_665906.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,676 Da
NCBI Official Full Name
high mobility group protein HMG-I/HMG-Y isoform a
NCBI Official Synonym Full Names
high mobility group AT-hook 1
NCBI Protein Information
high mobility group protein HMG-I/HMG-Y; HMG-I(Y); high mobility group protein R; high mobility group protein A1; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y; high-mobility group (nonhistone chromosomal) protein isoforms I and Y
UniProt Protein Name
High mobility group protein HMG-I/HMG-Y
UniProt Synonym Protein Names
High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R
UniProt Synonym Gene Names
UniProt Entry Name
HMGA1_HUMAN
NCBI Summary for HMGA2
This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for HMGA2
HMGA1: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions. A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51B. Belongs to the HMGA family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p21
Cellular Component: nucleoplasm; transcription factor complex; focal adhesion; nucleus; cytosol
Molecular Function: retinoid X receptor binding; peroxisome proliferator activated receptor binding; protein binding; enzyme binding; DNA-(apurinic or apyrimidinic site) lyase activity; ligand-dependent nuclear receptor transcription coactivator activity; DNA binding; AT DNA binding; retinoic acid receptor binding; 5'-deoxyribose-5-phosphate lyase activity; transcription factor binding
Biological Process: DNA unwinding during replication; negative regulation of cell proliferation; negative regulation of chromatin silencing; nucleosome disassembly; viral reproduction; transcription, DNA-dependent; regulation of transcription, DNA-dependent; base-excision repair; positive regulation of transcription, DNA-dependent; response to virus; protein complex assembly; negative regulation of transcription, DNA-dependent; DNA catabolic process, endonucleolytic
Research Articles on HMGA2
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Pathways associated with HMGA2 elisa kit
Diseases associated with HMGA2 elisa kit
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