NP_001124527.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,098 Da
NCBI Official Full Name
histamine H2 receptor isoform 1
NCBI Official Synonym Full Names
histamine receptor H2
NCBI Official Synonym Symbols
NCBI Protein Information
histamine H2 receptor; HH2R; gastric receptor 1; gastric receptor I
UniProt Protein Name
Histamine H2 receptor
UniProt Synonym Protein Names
Gastric receptor I
UniProt Synonym Gene Names
UniProt Entry Name
HRH2_HUMAN
NCBI Summary for HIS
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Comments for HIS
H2R: The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q35.2
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: histamine receptor activity
Biological Process: gland development; G-protein signaling, coupled to cyclic nucleotide second messenger; gastrin-induced gastric acid secretion; histamine-induced gastric acid secretion; gut development; positive regulation of vasoconstriction; regulation of synaptic plasticity; visual learning; immune response; memory
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Products associated with HIS elisa kit
Pathways associated with HIS elisa kit
Diseases associated with HIS elisa kit
Organs/Tissues associated with HIS elisa kit
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