NP_076921.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,574 Da
NCBI Official Full Name
homeobox protein Hox-B8
NCBI Official Synonym Full Names
homeobox B8
NCBI Protein Information
homeobox protein Hox-B8; homeo box 2D; homeo box B8; homeobox protein Hox-2D; homeobox protein Hox-2.4
UniProt Protein Name
Homeobox protein Hox-B8
UniProt Synonym Protein Names
Homeobox protein Hox-2.4; Homeobox protein Hox-2D
UniProt Synonym Gene Names
UniProt Entry Name
HXB8_HUMAN
NCBI Summary for HOXB8
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
UniProt Comments for HOXB8
HOXB8: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: nucleus
Molecular Function: sequence-specific DNA binding; transcription factor activity
Biological Process: grooming behavior; anterior/posterior pattern formation; dorsal spinal cord development; negative regulation of myeloid cell differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; adult locomotory behavior; sensory perception of pain; embryonic skeletal morphogenesis
Research Articles on HOXB8
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Products associated with HOXB8 elisa kit
Diseases associated with HOXB8 elisa kit
Organs/Tissues associated with HOXB8 elisa kit
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