NP_001269849.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,661 Da
NCBI Official Full Name
interferon-induced GTP-binding protein Mx1 isoform b
NCBI Official Synonym Full Names
MX dynamin like GTPase 1
NCBI Protein Information
interferon-induced GTP-binding protein Mx1
UniProt Protein Name
Interferon-induced GTP-binding protein Mx1
UniProt Synonym Protein Names
Interferon-induced protein p78; IFI-78K
UniProt Synonym Gene Names
UniProt Entry Name
MX1_HUMAN
NCBI Summary for MX1
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for MX1
MX1: Dynamin-like GTPase acting as a cell-autonomous host restriction factor against many viral pathogens. Shows activity against influenza viruses, rhabdovirus VSV, bunyavirus LACV, Thogoto virus, measles virus, Hantaan virus, Coxsackie virus CVB, Rift Valley fever virus RVFV, hepatitis B virus HBV, and Crimean- Congo hemorrhagic fever virus CCHFV. Belongs to the dynamin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; Hydrolase
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum membrane; nuclear membrane; perinuclear region of cytoplasm
Molecular Function: GTP binding; GTPase activity; protein binding
Biological Process: apoptosis; cytokine and chemokine mediated signaling pathway; defense response; defense response to virus; innate immune response; metabolic process; negative regulation of viral genome replication; response to virus; signal transduction
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Products associated with MX1 elisa kit
Pathways associated with MX1 elisa kit
Diseases associated with MX1 elisa kit
Organs/Tissues associated with MX1 elisa kit
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