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OX-A elisa kit :: Monkey Orexin A ELISA Kit

Scan QR to view Datasheet Catalog #    MBS016636 OX-A elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Orexin A (OX-A), ELISA Kit

 Also Known As   

Monkey Orexin A ELISA Kit

 Product Gene Name   

OX-A elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    161400
 3D Structure    ModBase 3D Structure for O43612
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of OX-A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for OX-A purchase    MBS016636 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Orexin A (OX-A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing OX-A. The ELISA analytical biochemical technique of the MBS016636 kit is based on OX-A antibody-OX-A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect OX-A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, OX-A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for OX-A. It may not necessarily be applicable to this product.
 NCBI GI #    4557635
 NCBI GeneID    3060
 NCBI Accession #    NP_001515.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001524.1 [Other Products]
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 UniProt Primary Accession #    O43612 [Other Products]
 UniProt Related Accession #    O43612 [Other Products]
 Molecular Weight    13,363 Da
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 NCBI Official Full Name    orexin
 NCBI Official Synonym Full Names    hypocretin (orexin) neuropeptide precursor
 NCBI Official Symbol    HCRT [Similar Products]
 NCBI Official Synonym Symbols   
OX; PPOX; NRCLP1
[Similar Products]
 NCBI Protein Information    orexin; prepro-orexin
 UniProt Protein Name    Orexin
 UniProt Synonym Protein Names   
Hypocretin; HcrtCleaved into the following 2 chains:Orexin-A; Alternative name(s):; Hypocretin-1; Hcrt1Orexin-B; Alternative name(s):; Hypocretin-2
 UniProt Gene Name    HCRT [Similar Products]
 UniProt Synonym Gene Names    OX; PPORX; PPOX; Hcrt; Hcrt1; Hcrt2 [Similar Products]
 UniProt Entry Name    OREX_HUMAN
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 NCBI Summary for OX-A    This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
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 UniProt Comments for OX-A    HCRT: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1). Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Belongs to the orexin family.

Protein type: Hormone

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: synaptic vesicle; rough endoplasmic reticulum; perinuclear region of cytoplasm; extracellular region; cell junction; secretory granule

Molecular Function: type 2 hypocretin receptor binding; type 1 hypocretin receptor binding

Biological Process: synaptic transmission; elevation of cytosolic calcium ion concentration; negative regulation of transmission of nerve impulse; eating behavior; neuropeptide signaling pathway; negative regulation of DNA replication; negative regulation of potassium ion transport; protein kinase C activation; regulation of neurotransmitter secretion; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; positive regulation of transmission of nerve impulse

Disease: Narcolepsy 1
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 Research Articles on OX-A    1. presence of CD4(+) T cells that are reactive to HCRT in narcolepsy patients and possible molecular mimicry between HCRT and a similar epitope in influenza pH1N1, pHA1275-287
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with OX-A elisa kitPathways associated with OX-A elisa kit
 Reference Product  PubMed Publications
 HCRTR1 elisa kit  >87 publications with OX-A and HCRTR1
 FOS elisa kit  >26 publications with OX-A and FOS
 TRH elisa kit  >2 publications with OX-A and TRH
 CCK elisa kit  >2 publications with OX-A and CCK
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway antibodies  Orexin And Neuropeptides FF And QRFP Bind To Their Respective Receptors Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with OX-A elisa kitOrgans/Tissues associated with OX-A elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >72 publications with OX-A and Nervous System Diseases
 Narcolepsy 1 Antibodies  >58 publications with OX-A and Narcolepsy 1
 Disease Models, Animal Antibodies  >12 publications with OX-A and Disease Models, Animal
 Bradycardia Antibodies  >8 publications with OX-A and Bradycardia
 Carcinoma Antibodies  >7 publications with OX-A and Carcinoma
 Cardiovascular Diseases Antibodies  >6 publications with OX-A and Cardiovascular Diseases
 Anxiety Disorders Antibodies  >6 publications with OX-A and Anxiety Disorders
 Pain Antibodies  >5 publications with OX-A and Pain
 Intestinal Diseases Antibodies  >5 publications with OX-A and Intestinal Diseases
 Weight Loss Antibodies  >4 publications with OX-A and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >195 publications with OX-A and Brain
 Connective Tissue Antibodies  >1 publications with OX-A and Connective Tissue
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