CAA65093.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,552 Da
NCBI Official Full Name
P-cadherin, partial
NCBI Official Synonym Full Names
cadherin 3, type 1, P-cadherin (placental)
NCBI Protein Information
cadherin-3; calcium-dependent adhesion protein, placental
UniProt Protein Name
Cadherin-3
UniProt Synonym Protein Names
Placental cadherin; P-cadherin
UniProt Synonym Gene Names
UniProt Entry Name
CADH3_HUMAN
NCBI Summary for P-Cadherin
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for P-Cadherin
CDH3: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Interacts with CDCP1. Expressed in some normal epithelial tissues and in some carcinoma cell lines. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: cell-cell adherens junction; cytoplasm; plasma membrane; integral to membrane
Molecular Function: calcium ion binding
Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to drug; intercellular junction assembly and maintenance; wound healing; positive regulation of melanin biosynthetic process; Wnt receptor signaling pathway through beta-catenin; hair cycle process; retinal homeostasis; negative regulation of transforming growth factor-beta2 production; cell-cell adhesion; negative regulation of catagen; positive regulation of monophenol monooxygenase activity; visual perception; keratinization; cell adhesion; homophilic cell adhesion
Disease: Ectodermal Dysplasia, Ectrodactyly, And Macular Dystrophy Syndrome; Hypotrichosis, Congenital, With Juvenile Macular Dystrophy
Research Articles on P-Cadherin
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Products associated with P-Cadherin elisa kit
Pathways associated with P-Cadherin elisa kit
Diseases associated with P-Cadherin elisa kit
Organs/Tissues associated with P-Cadherin elisa kit
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