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PKD2 elisa kit :: Monkey PKD2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2515446 PKD2 elisa kit
Unit / Price
48-Strip-Wells  /  $450 +1 FREE 8GB USB
96-Strip-Wells  /  $535 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,255 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,975 +4 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   


 Also Known As   

Monkey PKD2 (Protein Kinase D2) ELISA Kit

 Product Gene Name   

PKD2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    173910
 3D Structure    ModBase 3D Structure for Q13563
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 Species Reactivity    Monkey
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 Specificity    This kit recognizes natural and recombinant Monkey PKD2. No significant cross-reactivity or interference between Monkey PKD2 and analogues was observed.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    1.563-100ng/mL
 Sensitivity    Min: 0.938ng/mL; Max: 100ng/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PKD2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PKD2 purchase    MBS2515446 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the PKD2, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 1.563-100ng/mL in biological research samples containing PKD2, with an estimated sensitivity of Min: 0.938ng/mL; Max: 100ng/mL. The ELISA analytical biochemical technique of the MBS2515446 kit is based on PKD2 antibody-PKD2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PKD2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PKD2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PKD2 elisa kit

   Intended Uses: This ELISA kit applies to the in vitro quantitative determination of Monkey PKD2 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to PKD2. Standards or samples are added to the appropriate micro ELISA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for PKD2 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain PKD2, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of PKD2. You can calculate the concentration of PKD2 in the samples by comparing the OD of the samples to the standard curve.
Sample Manual Insert of MBS2515446. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PKD2. It may not necessarily be applicable to this product.
 NCBI GI #    4505835
 NCBI GeneID    5311
 NCBI Accession #    NP_000288.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000297.3 [Other Products]
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 UniProt Primary Accession #    Q13563 [Other Products]
 UniProt Secondary Accession #    O60441; Q15764; Q2M1Q3; Q2M1Q5 [Other Products]
 UniProt Related Accession #    Q13563 [Other Products]
 Molecular Weight    98,838 Da
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 NCBI Official Full Name    polycystin-2
 NCBI Official Synonym Full Names    polycystic kidney disease 2 (autosomal dominant)
 NCBI Official Symbol    PKD2 [Similar Products]
 NCBI Official Synonym Symbols   
PC2; PKD4; Pc-2; APKD2; TRPP2
[Similar Products]
 NCBI Protein Information    polycystin-2; R48321; autosomal dominant polycystic kidney disease type II protein; polycystwin; transient receptor potential cation channel, subfamily P, member 2
 UniProt Protein Name    Polycystin-2
 UniProt Synonym Protein Names   
Autosomal dominant polycystic kidney disease type II protein; Polycystic kidney disease 2 protein; Polycystwin; R48321
 Protein Family    Polycystin
 UniProt Gene Name    PKD2 [Similar Products]
 UniProt Entry Name    PKD2_HUMAN
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 NCBI Summary for PKD2    This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]
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 UniProt Comments for PKD2    PKD2: Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. Acts as a regulator of cilium length, together with PKD1. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. Functions as a calcium permeable cation channel. Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2). ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy. Belongs to the polycystin family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q22.1

Cellular Component: filamentous actin; endoplasmic reticulum membrane; integral to plasma membrane; endoplasmic reticulum; lamellipodium; nonmotile primary cilium; cytoplasm; motile primary cilium; plasma membrane; basal plasma membrane; intercellular junction; basal cortex; cilium

Molecular Function: voltage-gated cation channel activity; actinin binding; identical protein binding; protein homodimerization activity; phosphoprotein binding; voltage-gated ion channel activity; calcium ion binding; muscle alpha-actinin binding; ATPase binding; voltage-gated calcium channel activity; calcium-induced calcium release activity; protein binding; potassium channel activity; voltage-gated sodium channel activity; cytoskeletal protein binding; HLH domain binding; receptor binding

Biological Process: neural tube development; cytoplasmic sequestering of transcription factor; embryonic placenta development; positive regulation of inositol-1,4,5-triphosphate receptor activity; positive regulation of nitric oxide biosynthetic process; regulation of cAMP metabolic process; heart development; detection of mechanical stimulus; JAK-STAT cascade; liver development; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; regulation of cell proliferation; negative regulation of cell proliferation; spinal cord development; ureteric bud branching; release of sequestered calcium ion into cytosol; calcium ion transport; positive regulation of transcription from RNA polymerase II promoter; heart looping; determination of left/right symmetry; cell cycle arrest; centrosome duplication

Disease: Polycystic Kidney Disease 2
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 Research Articles on PKD2    1. TRPV4, TRPC1, and TRPP2 contribute to the ion permeation pore of the channels
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PKD2 elisa kitPathways associated with PKD2 elisa kit
 Reference Product  PubMed Publications
 PKD1 elisa kit  >850 publications with PKD2 and PKD1
 TRPC1 elisa kit  >9 publications with PKD2 and TRPC1
 TRPV4 elisa kit  >5 publications with PKD2 and TRPV4
 NEK8 elisa kit  >4 publications with PKD2 and NEK8
 ID2 elisa kit  >2 publications with PKD2 and ID2
 HAX1 elisa kit  >2 publications with PKD2 and HAX1
 RP2 elisa kit  >1 publications with PKD2 and RP2
 HERPUD1 elisa kit  >1 publications with PKD2 and HERPUD1
 CD2AP elisa kit  >1 publications with PKD2 and CD2AP
 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram
 VxPx Cargo-targeting To Cilium Pathway antibodies  VxPx Cargo-targeting To Cilium Pathway Diagram
Diseases associated with PKD2 elisa kitOrgans/Tissues associated with PKD2 elisa kit
 Disease Name  Pubmed Publications
 Polycystic Kidney, Autosomal Dominant Antibodies  >3563 publications with PKD2 and Polycystic Kidney, Autosomal Dominant
 Kidney Diseases Antibodies  >3236 publications with PKD2 and Kidney Diseases
 Hypertension Antibodies  >625 publications with PKD2 and Hypertension
 Vascular Diseases Antibodies  >554 publications with PKD2 and Vascular Diseases
 Renal Insufficiency Antibodies  >479 publications with PKD2 and Renal Insufficiency
 Nervous System Diseases Antibodies  >334 publications with PKD2 and Nervous System Diseases
 Brain Diseases Antibodies  >208 publications with PKD2 and Brain Diseases
 Heart Diseases Antibodies  >122 publications with PKD2 and Heart Diseases
 Carcinoma Antibodies  >88 publications with PKD2 and Carcinoma
 Abnormalities, Multiple Antibodies  >81 publications with PKD2 and Abnormalities, Multiple
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3654 publications with PKD2 and Kidney
 Liver Antibodies  >490 publications with PKD2 and Liver
 Vascular Antibodies  >278 publications with PKD2 and Vascular
 Heart Antibodies  >134 publications with PKD2 and Heart
 Brain Antibodies  >86 publications with PKD2 and Brain
 Pancreas Antibodies  >74 publications with PKD2 and Pancreas
 Muscle Antibodies  >74 publications with PKD2 and Muscle
 Embryonic Tissue Antibodies  >54 publications with PKD2 and Embryonic Tissue
 Bone Antibodies  >40 publications with PKD2 and Bone
 Skin Antibodies  >36 publications with PKD2 and Skin
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