NP_000297.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,669 Da
NCBI Official Full Name
pituitary-specific positive transcription factor 1 isoform alpha
NCBI Official Synonym Full Names
POU class 1 homeobox 1
NCBI Official Synonym Symbols
PIT1; CPHD1; GHF-1; Pit-1; POU1F1a [Similar Products]
NCBI Protein Information
pituitary-specific positive transcription factor 1; growth hormone factor 1; POU domain, class 1, transcription factor 1
UniProt Protein Name
Pituitary-specific positive transcription factor 1
UniProt Synonym Protein Names
Growth hormone factor 1; GHF-1
UniProt Synonym Gene Names
UniProt Entry Name
PIT1_HUMAN
NCBI Summary for POU1F1
This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for POU1F1
GHF-1: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'- TAAAT-3'. Belongs to the POU transcription factor family. Class- 1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 3p11
Cellular Component: nucleoplasm; cytoplasm
Molecular Function: chromatin binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; nuclear transport; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of inositol trisphosphate biosynthetic process; cell fate specification; determination of adult life span; negative regulation of transcription from RNA polymerase II promoter; positive regulation of multicellular organism growth; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; B cell differentiation; somatotropin secreting cell development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter
Disease: Pituitary Hormone Deficiency, Combined, 1
Research Articles on POU1F1
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Products associated with POU1F1 elisa kit
Pathways associated with POU1F1 elisa kit
Diseases associated with POU1F1 elisa kit
Disease Name |
Pubmed Publications |
Brain Diseases Antibodies |
>140 publications with POU1F1 and Brain Diseases |
Pituitary Hormone Deficiency, Combined, 1 Antibodies |
>82 publications with POU1F1 and Pituitary Hormone Deficiency, Combined, 1 |
Pituitary Hormone Deficiency, Combined, 2 Antibodies |
>31 publications with POU1F1 and Pituitary Hormone Deficiency, Combined, 2 |
Dwarfism, Pituitary Antibodies |
>18 publications with POU1F1 and Dwarfism, Pituitary |
Chromosome Aberrations Antibodies |
>7 publications with POU1F1 and Chromosome Aberrations |
Kidney Diseases Antibodies |
>7 publications with POU1F1 and Kidney Diseases |
Eye Diseases Antibodies |
>7 publications with POU1F1 and Eye Diseases |
Breast Neoplasms Antibodies |
>7 publications with POU1F1 and Breast Neoplasms |
Hyperplasia Antibodies |
>5 publications with POU1F1 and Hyperplasia |
Aneuploidy Antibodies |
>5 publications with POU1F1 and Aneuploidy |
Organs/Tissues associated with POU1F1 elisa kit
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