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PLP elisa kit :: Monkey Proteolipid Protein ELISA Kit

Scan QR to view Datasheet Catalog #    MBS011581 PLP elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Proteolipid Protein (PLP), ELISA Kit

 Also Known As   

Monkey Proteolipid Protein ELISA Kit

 Product Gene Name   

PLP elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: X; NC_000023.10 (103031439..103047548). Location: Xq22
 OMIM    300401
 3D Structure    ModBase 3D Structure for P60201
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PLP elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PLP purchase    MBS011581 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Proteolipid Protein (PLP) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PLP. The ELISA analytical biochemical technique of the MBS011581 kit is based on PLP antibody-PLP antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PLP antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PLP. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PLP. It may not necessarily be applicable to this product.
 NCBI GI #    387028
 NCBI GeneID    5354
 NCBI Accession #    AAA60350.1 [Other Products]
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 UniProt Primary Accession #    P60201 [Other Products]
 UniProt Secondary Accession #    P04400; P06905; Q502Y1; Q6FHZ6 [Other Products]
 UniProt Related Accession #    P60201 [Other Products]
 Molecular Weight    30,077 Da
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 NCBI Official Full Name    proteolipid protein, partial
 NCBI Official Synonym Full Names    proteolipid protein 1
 NCBI Official Symbol    PLP1 [Similar Products]
 NCBI Official Synonym Symbols   
PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20
[Similar Products]
 NCBI Protein Information    myelin proteolipid protein; lipophilin; major myelin proteolipid protein
 UniProt Protein Name    Myelin proteolipid protein
 UniProt Synonym Protein Names   
Lipophilin
 Protein Family    Proteolipid protein
 UniProt Gene Name    PLP1 [Similar Products]
 UniProt Synonym Gene Names    PLP; PLP [Similar Products]
 UniProt Entry Name    MYPR_HUMAN
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 NCBI Summary for PLP    This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLP    PLP1: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1); also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay. Defects in PLP1 are the cause of spastic paraplegia X- linked type 2 (SPG2). SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy. Belongs to the myelin proteolipid protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: plasma membrane; integral to membrane; myelin sheath

Molecular Function: structural constituent of myelin sheath; structural molecule activity

Biological Process: integrin-mediated signaling pathway; synaptic transmission; substantia nigra development; myelination in the central nervous system; cell maturation; long-chain fatty acid biosynthetic process; axon ensheathment; inflammatory response; astrocyte development

Disease: Spastic Paraplegia 2, X-linked; Pelizaeus-merzbacher Disease
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 Research Articles on PLP    1. data show that complex duplications involving PLP1 are not uncommon, can be detected at the level of genome resolution afforded by clinical aCGH and duplication and inversion can be produced in the same event.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PLP elisa kitPathways associated with PLP elisa kit
 Reference Product  PubMed Publications
 MBP elisa kit  >44 publications with PLP and MBP
 PLP2 elisa kit  >19 publications with PLP and PLP2
 MAG elisa kit  >14 publications with PLP and MAG
 GJC2 elisa kit  >7 publications with PLP and GJC2
 AIMP1 elisa kit  >1 publications with PLP and AIMP1
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
Diseases associated with PLP elisa kitOrgans/Tissues associated with PLP elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >190 publications with PLP and Nervous System Diseases
 Pelizaeus-Merzbacher Disease Antibodies  >129 publications with PLP and Pelizaeus-Merzbacher Disease
 Disease Models, Animal Antibodies  >78 publications with PLP and Disease Models, Animal
 Nerve Degeneration Antibodies  >20 publications with PLP and Nerve Degeneration
 Spastic paraplegia 2, X-linked Antibodies  >17 publications with PLP and Spastic paraplegia 2, X-linked
 Inflammation Antibodies  >12 publications with PLP and Inflammation
 Nervous System Malformations Antibodies  >11 publications with PLP and Nervous System Malformations
 Drug Toxicity Antibodies  >10 publications with PLP and Drug Toxicity
 Atrophy Antibodies  >8 publications with PLP and Atrophy
 Seizures Antibodies  >7 publications with PLP and Seizures
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >202 publications with PLP and Nerve
 Brain Antibodies  >154 publications with PLP and Brain
 Blood Antibodies  >40 publications with PLP and Blood
 Spinal Cord Antibodies  >35 publications with PLP and Spinal Cord
 Embryonic Tissue Antibodies  >22 publications with PLP and Embryonic Tissue
 Ganglia Antibodies  >7 publications with PLP and Ganglia
 Spleen Antibodies  >7 publications with PLP and Spleen
 Skin Antibodies  >7 publications with PLP and Skin
 Eye Antibodies  >6 publications with PLP and Eye
 Muscle Antibodies  >3 publications with PLP and Muscle
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