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SPB elisa kit :: Monkey Pulmonary Surfactant Associated Protein B ELISA Kit

Scan QR to view Datasheet Catalog #    MBS024325 SPB elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Pulmonary Surfactant Associated Protein B (SPB), ELISA Kit

 Also Known As   

Monkey Pulmonary Surfactant Associated Protein B ELISA Kit

 Product Gene Name   

SPB elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 2; NC_000002.11 (85884440..85895864, complement). Location: 2p12-p11.2
 OMIM    178640
 3D Structure    ModBase 3D Structure for P07988
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SPB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SPB purchase    MBS024325 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Pulmonary Surfactant Associated Protein B (SPB) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SPB. The ELISA analytical biochemical technique of the MBS024325 kit is based on SPB antibody-SPB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SPB antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SPB. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SPB. It may not necessarily be applicable to this product.
 NCBI GI #    288856299
 NCBI GeneID    6439
 NCBI Accession #    NP_000533.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000542.3 [Other Products]
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 UniProt Primary Accession #    P07988 [Other Products]
 UniProt Secondary Accession #    Q96R04 [Other Products]
 UniProt Related Accession #    P07988 [Other Products]
 Molecular Weight    42,117 Da
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 NCBI Official Full Name    pulmonary surfactant-associated protein B
 NCBI Official Synonym Full Names    surfactant protein B
 NCBI Official Symbol    SFTPB [Similar Products]
 NCBI Official Synonym Symbols   
SP-B; PSP-B; SFTB3; SFTP3; SMDP1
[Similar Products]
 NCBI Protein Information    pulmonary surfactant-associated protein B; 6 kDa protein; 18 kDa pulmonary-surfactant protein; pulmonary surfactant-associated proteolipid SPL(Phe)
 UniProt Protein Name    Pulmonary surfactant-associated protein B
 UniProt Synonym Protein Names   
18 kDa pulmonary-surfactant protein; 6 kDa protein; Pulmonary surfactant-associated proteolipid SPL(Phe)
 UniProt Gene Name    SFTPB [Similar Products]
 UniProt Synonym Gene Names    SFTP3; SP-B [Similar Products]
 UniProt Entry Name    PSPB_HUMAN
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 NCBI Summary for SPB    This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
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 UniProt Comments for SPB    SFTPB: Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. Defects in SFTPB are the cause of pulmonary surfactant metabolism dysfunction type 1 (SMDP1); also called pulmonary alveolar proteinosis due to surfactant protein B deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid- Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPB are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS). RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. A variation Ile to Thr at position 131 influences the association between specific alleles of SFTPA1 and respiratory distress syndrome in premature infants.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2p12-p11.2

Cellular Component: extracellular space; lysosome

Biological Process: organ morphogenesis; sphingolipid metabolic process; respiratory gaseous exchange

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 1
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 Research Articles on SPB    1. Mutations in exon 4 of the surfactant protein B gene demonstrate an association between homozygous mutations with C/C genotype in SP-B gene and neonatal respiratory distress.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SPB elisa kitDiseases associated with SPB elisa kit
 Reference Product  PubMed Publications
 SFTPC elisa kit  >24 publications with SPB and SFTPC
 ABCA3 elisa kit  >12 publications with SPB and ABCA3
 SFTPA1 elisa kit  >6 publications with SPB and SFTPA1
 SFTPD elisa kit  >6 publications with SPB and SFTPD
 NKX2-1 elisa kit  >5 publications with SPB and NKX2-1
 PROSP elisa kit  >3 publications with SPB and PROSP
 SCGB1A1 elisa kit  >1 publications with SPB and SCGB1A1
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >35 publications with SPB and Lung Diseases
 Neoplasms Antibodies  >9 publications with SPB and Neoplasms
 Inflammation Antibodies  >6 publications with SPB and Inflammation
 Lung Injury Antibodies  >5 publications with SPB and Lung Injury
 Lung Neoplasms Antibodies  >5 publications with SPB and Lung Neoplasms
 Acute Lung Injury Antibodies  >3 publications with SPB and Acute Lung Injury
 Necrosis Antibodies  >3 publications with SPB and Necrosis
 Pneumonia Antibodies  >3 publications with SPB and Pneumonia
 Drug Toxicity Antibodies  >3 publications with SPB and Drug Toxicity
 Hypertension Antibodies  >2 publications with SPB and Hypertension
Organs/Tissues associated with SPB elisa kit
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >59 publications with SPB and Lung
 Thyroid Antibodies  >12 publications with SPB and Thyroid
 Brain Antibodies  >4 publications with SPB and Brain
 Eye Antibodies  >1 publications with SPB and Eye
 Connective Tissue Antibodies  >1 publications with SPB and Connective Tissue
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