NP_035489.2
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
Molecular Weight
21,055 Da
NCBI Official Full Name
pulmonary surfactant-associated protein C
NCBI Official Synonym Full Names
surfactant associated protein C
NCBI Official Synonym Symbols
SP5; SPC; SP-C; Sftp2; Bricd6; Sftp-2; pro-SpC [Similar Products]
NCBI Protein Information
pulmonary surfactant-associated protein C; pulmonary surfactant-associated proteolipid SPL(Val)
UniProt Protein Name
Pulmonary surfactant-associated protein C
UniProt Synonym Protein Names
Pulmonary surfactant-associated proteolipid SPL(Val); SP5
UniProt Synonym Gene Names
UniProt Entry Name
PSPC_MOUSE
UniProt Comments for SPC
SFTPC: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. Defects in SFTPC are the cause of pulmonary surfactant metabolism dysfunction type 2 (SMDP2); also called pulmonary alveolar proteinosis due to surfactant protein C deficiency. A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Genetic variations in SFTPC are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid-binding
Cellular Component: multivesicular body; extracellular space; cytoplasm; extracellular region
Molecular Function: protein homodimerization activity
Biological Process: protein homooligomerization
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Products associated with SPC elisa kit
Organs/Tissues associated with SPC elisa kit
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