NP_002936.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,138 Da
NCBI Official Full Name
replication protein A 70 kDa DNA-binding subunit
NCBI Official Synonym Full Names
replication protein A1, 70kDa
NCBI Official Synonym Symbols
HSSB; RF-A; RP-A; REPA1; RPA70; MST075 [Similar Products]
NCBI Protein Information
replication protein A 70 kDa DNA-binding subunit; MSTP075; RP-A p70; RF-A protein 1; replication factor A protein 1; single-stranded DNA-binding protein
UniProt Protein Name
Replication protein A 70 kDa DNA-binding subunit
UniProt Synonym Protein Names
Replication factor A protein 1; RF-A protein 1; Single-stranded DNA-binding proteinCleaved into the following chain:Replication protein A 70 kDa DNA-binding subunit, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
RFA1_HUMAN
UniProt Comments for RPA1
RPA1: Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing. Heterotrimer composed of RPA1, RPA2 and RPA3 (canonical replication protein A complex). Component of the alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside exclusively on the RPA1 subunit. Interacts with RIPK1 and XPA. Interacts with RPA4. Interacts with the polymerase alpha subunit POLA1/p180; this interaction stabilizes the replicative complex and reduces the misincorporation rate of DNA polymerase alpha by acting as a fidelity clamp. Interact with RAD51 and SENP6 to regulate DNA repair. Interacts with HELB; this interaction promotes HELB recruitement to chromatin following DNA damage. Belongs to the replication factor A protein 1 family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: male germ cell nucleus; nucleoplasm; lateral element; PML body; DNA replication factor A complex; nucleus
Molecular Function: protein binding; metal ion binding; damaged DNA binding; chromatin binding; single-stranded DNA binding
Biological Process: meiosis; mismatch repair; in utero embryonic development; DNA strand elongation during DNA replication; DNA repair; double-strand break repair via homologous recombination; DNA recombination; telomere maintenance via semi-conservative replication; DNA recombinase assembly; base-excision repair; nucleotide-excision repair; homeostasis of number of cells within a tissue; transcription-coupled nucleotide-excision repair; double-strand break repair; positive regulation of cell proliferation; telomere maintenance via recombination; nucleotide-excision repair, DNA damage removal; hemopoiesis; nucleotide-excision repair, DNA gap filling; mitotic cell cycle; DNA replication; DNA-dependent DNA replication; telomere maintenance; G1/S transition of mitotic cell cycle
Research Articles on RPA1
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