NP_000532.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,120 Da
NCBI Official Full Name
S-arrestin
NCBI Official Synonym Full Names
S-antigen; retina and pineal gland (arrestin)
NCBI Official Synonym Symbols
NCBI Protein Information
S-arrestin; arrestin 1; 48 kDa protein; rod photoreceptor arrestin; retinal S-antigen (48 KDa protein)
UniProt Protein Name
S-arrestin
UniProt Synonym Protein Names
48 kDa protein; Retinal S-antigen; S-AG; Rod photoreceptor arrestin
UniProt Synonym Gene Names
UniProt Entry Name
ARRS_HUMAN
NCBI Summary for SAG
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal recessive form of night blindness. [provided by RefSeq, Jul 2008]
UniProt Comments for SAG
SAG: Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Retina and pineal gland. Belongs to the arrestin family.
Protein type: G protein regulator, misc.; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q37.1
Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cytosol
Molecular Function: opsin binding; phosphoprotein binding; protein phosphatase inhibitor activity
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; cell surface receptor linked signal transduction; visual perception; negative regulation of catalytic activity
Disease: Oguchi Disease 1; Retinitis Pigmentosa 47
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with SAG elisa kit
Pathways associated with SAG elisa kit
Diseases associated with SAG elisa kit
Organs/Tissues associated with SAG elisa kit
|