NP_062218.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
110,554 Da
NCBI Official Full Name
solute carrier family 12 member 3
NCBI Official Synonym Full Names
solute carrier family 12 member 3
NCBI Official Synonym Symbols
NCBI Protein Information
solute carrier family 12 member 3
UniProt Protein Name
Solute carrier family 12 member 3
UniProt Synonym Protein Names
Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter
UniProt Synonym Gene Names
NCBI Summary for SLC12A3
mediates thiazide-sensitive cotransport of sodium and chloride; may play a role in the metabolism of NaCl and other electrolytes [RGD, Feb 2006]
UniProt Comments for SLC12A3
NCCT: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 19p13-p12
Cellular Component: apical plasma membrane; cytosol; integral component of membrane; plasma membrane; vesicle
Molecular Function: cation:chloride symporter activity; enzyme binding; sodium ion transmembrane transporter activity; sodium:chloride symporter activity; transporter activity
Biological Process: chloride transport; sodium ion transport
Research Articles on SLC12A3
Precautions
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Pathways associated with SLC12A3 elisa kit
Diseases associated with SLC12A3 elisa kit
Organs/Tissues associated with SLC12A3 elisa kit
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