NP_904358.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,859 Da
NCBI Official Full Name
TSC22 domain family protein 1 isoform 1
NCBI Official Synonym Full Names
TSC22 domain family, member 1
NCBI Protein Information
TSC22 domain family protein 1; TGFB-stimulated clone 22 homolog; TGFbeta-stimulated clone 22; cerebral protein 2; regulatory protein TSC-22; transcriptional regulator TSC-22; transforming growth factor beta-1-induced transcript 4 protein; transforming growth factor beta-stimulated protein TSC-22
UniProt Protein Name
TSC22 domain family protein 1
UniProt Synonym Protein Names
Cerebral protein 2; Regulatory protein TSC-22; TGFB-stimulated clone 22 homolog; Transforming growth factor beta-1-induced transcript 4 protein
UniProt Synonym Gene Names
UniProt Entry Name
T22D1_HUMAN
NCBI Summary for TSC22
This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
UniProt Comments for TSC22
TSC22D1: Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. Belongs to the TSC-22/Dip/Bun family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 13q14
Cellular Component: cytoplasm; nucleus
Molecular Function: protein binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of cell proliferation; negative regulation of apoptosis
Research Articles on TSC22
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Products associated with TSC22 elisa kit
Diseases associated with TSC22 elisa kit
Organs/Tissues associated with TSC22 elisa kit
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