NP_000349.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,681 Da
NCBI Official Full Name
transforming growth factor-beta-induced protein ig-h3
NCBI Official Synonym Full Names
transforming growth factor, beta-induced, 68kDa
NCBI Official Synonym Symbols
CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1 [Similar Products]
NCBI Protein Information
transforming growth factor-beta-induced protein ig-h3; RGD-CAP; beta ig-h3; kerato-epithelin; RGD-containing collagen-associated protein; transforming growth factor, beta-induced, 68kD
UniProt Protein Name
Transforming growth factor-beta-induced protein ig-h3
UniProt Synonym Protein Names
Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP
UniProt Synonym Gene Names
UniProt Entry Name
BGH3_HUMAN
NCBI Summary for TGFbI
This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for TGFbI
betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium.
Protein type: Secreted, signal peptide; Extracellular matrix; Cell adhesion; Secreted
Chromosomal Location of Human Ortholog: 5q31
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; plasma membrane; extracellular region; basement membrane; trans-Golgi network
Molecular Function: collagen binding; integrin binding; protein binding; extracellular matrix binding
Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; negative regulation of cell adhesion; angiogenesis; cell adhesion
Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy, Avellino Type; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I
Research Articles on TGFbI
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Products associated with TGFbI elisa kit
Pathways associated with TGFbI elisa kit
Diseases associated with TGFbI elisa kit
Organs/Tissues associated with TGFbI elisa kit
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