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TP63 elisa kit :: Monkey Tumor Protein P63 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS740368 TP63 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor Protein P63 (TP63), ELISA Kit

 Also Known As   

Monkey Tumor Protein P63 ELISA Kit

 Product Gene Name   

TP63 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    605289
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 Species Reactivity    Monkey
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
 Assay Type    Sandwich
 Detection Range    250-5000pg/mL
 Sensitivity    1.0pg/mL
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of TP63 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for TP63 purchase    MBS740368 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tumor Protein P63 (TP63) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 250-5000pg/mL in biological research samples containing TP63, with an estimated sensitivity of 1.0pg/mL. The ELISA analytical biochemical technique of the MBS740368 kit is based on TP63 antibody-TP63 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TP63 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TP63. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for TP63 elisa kit    Cancer
NCBI/Uniprot data below describe general gene information for TP63. It may not necessarily be applicable to this product.
 NCBI GI #    169234665
 NCBI GeneID    8626
 NCBI Accession #    NP_001108454.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114982.1 [Other Products]
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 UniProt Secondary Accession #    O75080; O75195; O75922; O76078; Q6VEG2; Q6VEG3; Q6VEG4; Q6VFJ1; Q6VFJ2; Q6VFJ3; Q6VH20 [Other Products]
 UniProt Related Accession #    Q9H3D4 [Other Products]
 Molecular Weight    65,288 Da
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 NCBI Official Full Name    tumor protein 63 isoform 6
 NCBI Official Synonym Full Names    tumor protein p63
 NCBI Official Symbol    TP63 [Similar Products]
 NCBI Official Synonym Symbols   
AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B)
[Similar Products]
 NCBI Protein Information    tumor protein 63; CUSP; transformation-related protein 63; tumor protein p53-competing protein; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; tumor protein p63 deltaN isoform delta
 UniProt Protein Name    Tumor protein 63
 UniProt Synonym Protein Names   
Chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p40; p51
 Protein Family    Tumor protein
 UniProt Gene Name    TP63 [Similar Products]
 UniProt Synonym Gene Names    KET; P63; P73H; P73L; TP73L; p63; CUSP; TP63; p73L [Similar Products]
 UniProt Entry Name    P63_HUMAN
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 NCBI Summary for TP63    This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TP63    p63: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L. Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. Belongs to the p53 family. 12 isoforms of the human protein are produced by alternative promoter.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: nucleoplasm; transcription factor complex; rough endoplasmic reticulum; nuclear chromatin; cytoplasm; dendrite; nucleus; chromatin; cytosol

Molecular Function: identical protein binding; protein binding; DNA binding; sequence-specific DNA binding; p53 binding; metal ion binding; double-stranded DNA binding; damaged DNA binding; WW domain binding; chromatin binding; transcription factor activity

Biological Process: G1 DNA damage checkpoint; ectoderm and mesoderm interaction; apoptosis; positive regulation of transcription, DNA-dependent; cloacal septation; epidermal cell division; negative regulation of transcription from RNA polymerase II promoter; regulation of caspase activity; protein homotetramerization; smooth muscle development; polarized epithelial cell differentiation; sympathetic nervous system development; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of mesenchymal cell proliferation; regulation of neuron apoptosis; epithelial cell development; response to gamma radiation; establishment of planar polarity; female genitalia morphogenesis; skeletal development; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; proximal/distal pattern formation; positive regulation of Notch signaling pathway; embryonic limb morphogenesis; response to X-ray; Notch signaling pathway; regulation of epidermal cell division; hair follicle morphogenesis; urinary bladder development; transcription, DNA-dependent; negative regulation of keratinocyte differentiation; multicellular organismal aging; keratinocyte proliferation; replicative cell aging; odontogenesis of dentine-containing teeth; chromatin remodeling; keratinocyte differentiation; positive regulation of osteoblast differentiation; neuron apoptosis; spermatogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; response to DNA damage stimulus; negative regulation of apoptosis

Disease: Ankyloblepharon-ectodermal Defects-cleft Lip/palate; Rapp-hodgkin Syndrome; Adult Syndrome; Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/palate Syndrome 3; Split-hand/foot Malformation 4; Limb-mammary Syndrome
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 Research Articles on TP63    1. biology of p63 and p73 in cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with TP63 elisa kitDiseases associated with TP63 elisa kit
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 TP53 Network Pathway antibodies  TP53 Network Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >405 publications with TP63 and Carcinoma
 Neoplasms, Squamous Cell Antibodies  >246 publications with TP63 and Neoplasms, Squamous Cell
 Carcinoma, Squamous Cell Antibodies  >231 publications with TP63 and Carcinoma, Squamous Cell
 Adenocarcinoma Antibodies  >160 publications with TP63 and Adenocarcinoma
 Abnormalities, Multiple Antibodies  >120 publications with TP63 and Abnormalities, Multiple
 Skin Abnormalities Antibodies  >103 publications with TP63 and Skin Abnormalities
 Breast Neoplasms Antibodies  >90 publications with TP63 and Breast Neoplasms
 Cleft Palate Antibodies  >86 publications with TP63 and Cleft Palate
 Cleft Lip Antibodies  >84 publications with TP63 and Cleft Lip
 Lung Neoplasms Antibodies  >81 publications with TP63 and Lung Neoplasms
Organs/Tissues associated with TP63 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >177 publications with TP63 and Skin
 Lung Antibodies  >101 publications with TP63 and Lung
 Eye Antibodies  >81 publications with TP63 and Eye
 Prostate Antibodies  >70 publications with TP63 and Prostate
 Mouth Antibodies  >63 publications with TP63 and Mouth
 Embryonic Tissue Antibodies  >50 publications with TP63 and Embryonic Tissue
 Lymph Antibodies  >42 publications with TP63 and Lymph
 Muscle Antibodies  >40 publications with TP63 and Muscle
 Bladder Antibodies  >39 publications with TP63 and Bladder
 Thyroid Antibodies  >33 publications with TP63 and Thyroid
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