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XBP1 elisa kit :: Monkey X-Box Binding Protein 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS021196 XBP1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

X-Box Binding Protein 1 (XBP1), ELISA Kit

 Also Known As   

Monkey X-Box Binding Protein 1 ELISA Kit

 Product Gene Name   

XBP1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 Chromosome Location    Chromosome: 22; NC_000022.10 (29190548..29196560, complement). Location: 22q12.1; 22q12
 OMIM    194355
 3D Structure    ModBase 3D Structure for P17861
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 Species Reactivity    Monkey
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of XBP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for XBP1 purchase    MBS021196 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the X-Box Binding Protein 1 (XBP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing XBP1. The ELISA analytical biochemical technique of the MBS021196 kit is based on XBP1 antibody-XBP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect XBP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, XBP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for XBP1. It may not necessarily be applicable to this product.
 NCBI GI #    47678753
 NCBI GeneID    7494
 NCBI Accession #    CAG30497.1 [Other Products]
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 UniProt Primary Accession #    P17861 [Other Products]
 UniProt Secondary Accession #    Q8WYK6; Q969P1; Q96BD7 [Other Products]
 UniProt Related Accession #    P17861 [Other Products]
 Molecular Weight    28,695 Da
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 NCBI Official Full Name    XBP1
 NCBI Official Synonym Full Names    X-box binding protein 1
 NCBI Official Symbol    XBP1 [Similar Products]
 NCBI Official Synonym Symbols   
XBP2; TREB5; XBP-1
[Similar Products]
 NCBI Protein Information    X-box-binding protein 1; tax-responsive element-binding protein 5
 UniProt Protein Name    X-box-binding protein 1
 UniProt Synonym Protein Names   
Tax-responsive element-binding protein 5
 Protein Family    X-box-binding protein
 UniProt Gene Name    XBP1 [Similar Products]
 UniProt Synonym Gene Names    TREB5; XBP2; XBP-1 [Similar Products]
 UniProt Entry Name    XBP1_HUMAN
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 NCBI Summary for XBP1    This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
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 UniProt Comments for XBP1    XBP1: a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 22q12.1|22q12

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasm; integral to membrane; integral to endoplasmic reticulum membrane; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; protease binding; DNA binding; protein heterodimerization activity; chromatin DNA binding; ubiquitin protein ligase binding; estrogen receptor binding; transcription factor activity; protein kinase binding

Biological Process: transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; phosphoinositide 3-kinase cascade; muscle development; apoptosis; exocrine pancreas development; positive regulation of transcription of target genes involved in unfolded protein response; regulation of protein stability; negative regulation of transcription from RNA polymerase II promoter; cellular response to glucose starvation; protein transport; serotonin secretion, neurotransmission; positive regulation of MHC class II biosynthetic process; positive regulation of transcription factor import into nucleus; angiogenesis; cell growth; response to electrical stimulus; fatty acid biosynthetic process; positive regulation of autophagy; positive regulation of TOR signaling pathway; response to drug; positive regulation of histone methylation; protein destabilization; unfolded protein response; organelle organization and biogenesis; cellular response to nutrient; positive regulation of immunoglobulin secretion; liver development; cholesterol homeostasis; positive regulation of immunoglobulin production; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cellular response to insulin stimulus; positive regulation of T cell differentiation; endothelial cell proliferation; fatty acid homeostasis; positive regulation of fat cell differentiation; autophagy; neuron development; positive regulation of B cell differentiation; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; sterol homeostasis; negative regulation of apoptosis

Disease: Major Affective Disorder 7
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 Research Articles on XBP1    1. Suppression of UBC9 expression by RNA interference reduced both the expression of pXBP1(S) and ER stress-induced transcription by pXBP1
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with XBP1 elisa kitPathways associated with XBP1 elisa kit
 Reference Product  PubMed Publications
 ATF6 elisa kit  >122 publications with XBP1 and ATF6
 DDIT3 elisa kit  >105 publications with XBP1 and DDIT3
 JUN elisa kit  >86 publications with XBP1 and JUN
 ERN1 elisa kit  >50 publications with XBP1 and ERN1
 FOXA1 elisa kit  >5 publications with XBP1 and FOXA1
 VEGFA elisa kit  >3 publications with XBP1 and VEGFA
 ESR1 elisa kit  >3 publications with XBP1 and ESR1
 Products by Pathway  Pathway Diagram
 Activation Of Chaperone Genes By ATF6-alpha Pathway antibodies  Activation Of Chaperone Genes By ATF6-alpha Pathway Diagram
 Activation Of Chaperone Genes By XBP1(S) Pathway antibodies  Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
 Activation Of Chaperones By ATF6-alpha Pathway antibodies  Activation Of Chaperones By ATF6-alpha Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with XBP1 elisa kitOrgans/Tissues associated with XBP1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >92 publications with XBP1 and Neoplasms
 Cardiovascular Diseases Antibodies  >44 publications with XBP1 and Cardiovascular Diseases
 Inflammation Antibodies  >42 publications with XBP1 and Inflammation
 Liver Diseases Antibodies  >36 publications with XBP1 and Liver Diseases
 Brain Diseases Antibodies  >34 publications with XBP1 and Brain Diseases
 Disease Models, Animal Antibodies  >30 publications with XBP1 and Disease Models, Animal
 Drug Toxicity Antibodies  >29 publications with XBP1 and Drug Toxicity
 Fatty Liver Antibodies  >17 publications with XBP1 and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >17 publications with XBP1 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >16 publications with XBP1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >80 publications with XBP1 and Blood
 Liver Antibodies  >60 publications with XBP1 and Liver
 Brain Antibodies  >60 publications with XBP1 and Brain
 Pancreas Antibodies  >28 publications with XBP1 and Pancreas
 Muscle Antibodies  >25 publications with XBP1 and Muscle
 Nerve Antibodies  >24 publications with XBP1 and Nerve
 Bone Antibodies  >22 publications with XBP1 and Bone
 Intestine Antibodies  >19 publications with XBP1 and Intestine
 Vascular Antibodies  >18 publications with XBP1 and Vascular
 Kidney Antibodies  >16 publications with XBP1 and Kidney
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