NP_001035831.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
24,327 Da
NCBI Official Full Name
DNA dC->dU-editing enzyme APOBEC-3H
NCBI Official Synonym Symbols
NCBI Protein Information
DNA dC->dU-editing enzyme APOBEC-3H; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H
UniProt Protein Name
DNA dC->dU-editing enzyme APOBEC-3H
UniProt Synonym Protein Names
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H
UniProt Entry Name
ABC3H_MACMU
UniProt Comments for APOBEC3H
Function: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA.3 PublicationsManual assertion based on experiment in:Ref.1
Catalytic activity: Cytidine + H2O = uridine + NH3.
Cofactor: Zinc
Enzyme regulation: Antiviral activity is neutralized by the simian immunodeficiency virus rhesus (SIV-mac) virion infectivity factor (VIF).1 PublicationManual assertion based on experiment in:Ref.4
Research Articles on APOBEC3H
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Organs/Tissues associated with APOBEC3H elisa kit
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