NP_003003.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,386 Da
NCBI Official Full Name
secreted frizzled-related protein 1
NCBI Official Synonym Full Names
secreted frizzled-related protein 1
NCBI Protein Information
secreted frizzled-related protein 1; SARP-2; sFRP-1; secreted apoptosis-related protein 2
UniProt Protein Name
Secreted frizzled-related protein 1
UniProt Synonym Protein Names
Secreted apoptosis-related protein 2; SARP-2
UniProt Synonym Gene Names
UniProt Entry Name
SFRP1_HUMAN
NCBI Summary for SFRP1
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
UniProt Comments for SFRP1
Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase In kidney development, inhibits tubule formation and bud growth in metanephroi Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Research Articles on SFRP1
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Products associated with SFRP1 elisa kit
Pathways associated with SFRP1 elisa kit
Diseases associated with SFRP1 elisa kit
Organs/Tissues associated with SFRP1 elisa kit
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