NP_001139302.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
136,309 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform 1
NCBI Official Synonym Full Names
phospholipase C, beta 1
NCBI Official Synonym Symbols
Plcb; AI132408; mKIAA0581; 3110043I21Rik [Similar Products]
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
UniProt Synonym Protein Names
PLC-154; Phosphoinositide phospholipase C-beta-1; Phospholipase C-beta-1; PLC-beta-1
UniProt Synonym Gene Names
UniProt Entry Name
PLCB1_MOUSE
UniProt Comments for Plcb1
PLCB1: an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11
Cellular Component: cytoplasm; cytosol; membrane; myelin sheath; nuclear chromatin; nuclear speck; nucleus
Molecular Function: calcium ion binding; calmodulin binding; enzyme binding; GTPase activator activity; hydrolase activity; lamin binding; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide phospholipase C activity; phosphoric diester hydrolase activity; protein binding; protein homodimerization activity; signal transducer activity
Biological Process: acetylcholine receptor signaling, muscarinic pathway; brain development; cell adhesion; cerebral cortex development; erythrocyte differentiation; fat cell differentiation; G2/M transition of mitotic cell cycle; glutamate signaling pathway; insulin receptor signaling pathway; insulin-like growth factor receptor signaling pathway; lipid catabolic process; lipid metabolic process; macrophage differentiation; memory; mRNA processing; negative regulation of transcription, DNA-dependent; oocyte maturation; positive regulation of developmental growth; positive regulation of embryonic development; positive regulation of GTPase activity; positive regulation of interleukin-12 production; positive regulation of JNK cascade; positive regulation of myoblast differentiation; positive regulation of sodium:hydrogen antiporter activity; positive regulation of transcription, DNA-dependent; regulation of cell cycle; regulation of G-protein coupled receptor protein signaling pathway; response to peptide hormone stimulus; signal transduction
Research Articles on Plcb1
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