NP_067255.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
149,668 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
NCBI Official Synonym Full Names
phospholipase C, gamma 1
NCBI Official Synonym Symbols
Cded; Plc-1; Plcg-1; AI894140; Plc-gamma1 [Similar Products]
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
UniProt Synonym Protein Names
Phosphoinositide phospholipase C-gamma-1; Phospholipase C-gamma-1; PLC-gamma-1
UniProt Synonym Gene Names
UniProt Entry Name
PLCG1_MOUSE
UniProt Comments for Plcg1
PLCG1: a calcium dependent phosphatidylinositol-specific phospholipase C. The activated enzyme produces the second messenger molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylated and activated by tyrosine kinases in response to signaling through a variety of growth factor receptors and immune system receptors.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase
Cellular Component: cell projection; cytoplasm; cytosol; intercellular junction; lamellipodium; neuron projection; plasma membrane; ruffle; signalosome
Molecular Function: calcium ion binding; glutamate receptor binding; hydrolase activity; insulin receptor binding; metal ion binding; neurotrophin TRKA receptor binding; phosphoinositide phospholipase C activity; phosphoprotein binding; phosphoric diester hydrolase activity; protein binding; protein kinase binding; receptor tyrosine kinase binding; signal transducer activity
Biological Process: calcium ion transport; calcium-mediated signaling; cell migration; epidermal growth factor receptor signaling pathway; in utero embryonic development; inositol trisphosphate biosynthetic process; lipid catabolic process; lipid metabolic process; phospholipid catabolic process; positive regulation of angiogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of release of sequestered calcium ion into cytosol; protein secretion; signal transduction; T cell receptor signaling pathway
Research Articles on Plcg1
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