NP_055106.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,974 Da
NCBI Official Full Name
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial isoform 2
NCBI Official Synonym Full Names
glycine C-acetyltransferase
NCBI Official Synonym Symbols
NCBI Protein Information
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; aminoacetone synthase; glycine acetyltransferase; 2-amino-3-ketobutyrate-CoA ligase
UniProt Protein Name
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
UniProt Synonym Protein Names
Aminoacetone synthase; Glycine acetyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
KBL_HUMAN
NCBI Summary for GCAT
The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
UniProt Comments for GCAT
GCAT: The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14. [provided by RefSeq, Jan 2010]
Protein type: EC 2.3.1.29; Amino Acid Metabolism - glycine, serine and threonine; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: nucleoplasm; mitochondrion
Molecular Function: glycine C-acetyltransferase activity; pyridoxal phosphate binding
Biological Process: amino acid metabolic process; biosynthetic process; threonine catabolic process to pyruvate
Research Articles on GCAT
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Pathways associated with GCAT elisa kit
Diseases associated with GCAT elisa kit
Organs/Tissues associated with GCAT elisa kit
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