NP_444502.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,112 Da
NCBI Official Full Name
delta(24)-sterol reductase
NCBI Official Synonym Full Names
24-dehydrocholesterol reductase
NCBI Official Synonym Symbols
mKIAA0018; 2310076D10Rik; 5830417J06Rik [Similar Products]
NCBI Protein Information
delta(24)-sterol reductase; delta(24)-sterol reductase; seladin-1; 3-beta-hydroxysterol delta-24 reductase; 3-beta-hydroxysterol delta-24-reductase
UniProt Protein Name
Delta(24)-sterol reductase
UniProt Synonym Protein Names
24-dehydrocholesterol reductase; 3-beta-hydroxysterol delta-24-reductase
UniProt Synonym Gene Names
UniProt Entry Name
DHC24_MOUSE
UniProt Comments for DHCR24
Diminuto: the enzyme 3-beta-hydroxysterol delta-24-reductase (DHCR24), a member of the flavin adenine dinucleotide (FAD)-dependent oxidoreductases, catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. Overexpressed in the adenoma tissue of patients with Cushing's syndrome. May be involved in the molecular events of adrenocortical tumorigenesis by facilitating steroid synthesis and cell growth.
Protein type: Membrane protein, integral; Oxidoreductase; EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis
Cellular Component: Golgi apparatus; cytoskeleton; membrane; endoplasmic reticulum; cytoplasm; integral to membrane; cytosol; nucleus
Molecular Function: delta24(24-1) sterol reductase activity; UDP-N-acetylmuramate dehydrogenase activity; enzyme binding; peptide antigen binding; FAD binding; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; delta24-sterol reductase activity; oxidoreductase activity; catalytic activity; oxidoreductase activity, acting on CH-OH group of donors
Biological Process: skin development; steroid metabolic process; tissue development; cholesterol metabolic process; negative regulation of caspase activity; cholesterol biosynthetic process; negative regulation of cell proliferation; protein localization; amyloid precursor protein catabolic process; sterol biosynthetic process; Ras protein signal transduction; male genitalia development; lipid metabolic process; sterol metabolic process; steroid biosynthetic process; plasminogen activation; negative regulation of apoptosis
Research Articles on DHCR24
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Products associated with DHCR24 elisa kit
Pathways associated with DHCR24 elisa kit
Diseases associated with DHCR24 elisa kit
Organs/Tissues associated with DHCR24 elisa kit
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