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PSMC4 elisa kit :: Mouse 26S protease regulatory subunit 6B (PSMC4) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS7238015 PSMC4 elisa kit
Unit / Price
48-Strip-Wells  /  $440 +1 FREE 8GB USB
96-Strip-Wells  /  $640 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,895 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,415 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

26S protease regulatory subunit 6B (PSMC4), ELISA Kit

 Also Known As   

Mouse 26S protease regulatory subunit 6B (PSMC4) ELISA Kit

 Product Gene Name   

PSMC4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    602707
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 Species Reactivity    Mouse
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 Samples    Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
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 Preparation and Storage    Store all reagents at 2-8 degree C.
 Sample Preparation    We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PSMC4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PSMC4 purchase    MBS7238015 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 26S protease regulatory subunit 6B (PSMC4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PSMC4. The ELISA analytical biochemical technique of the MBS7238015 kit is based on PSMC4 antibody-PSMC4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PSMC4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PSMC4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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 Product Categories/Family for PSMC4 elisa kit    Cell Biology
NCBI/Uniprot data below describe general gene information for PSMC4. It may not necessarily be applicable to this product.
 NCBI GI #    5729991
 NCBI GeneID    5704
 NCBI Accession #    NP_006494.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_006503.3 [Other Products]
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 UniProt Secondary Accession #    Q96FV5; Q9UBM3; Q9UEX3 [Other Products]
 UniProt Related Accession #    P43686 [Other Products]
 Molecular Weight    43,508 Da
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 NCBI Official Full Name    26S protease regulatory subunit 6B isoform 1
 NCBI Official Synonym Full Names    proteasome (prosome, macropain) 26S subunit, ATPase, 4
 NCBI Official Symbol    PSMC4 [Similar Products]
 NCBI Official Synonym Symbols   
S6; RPT3; TBP7; TBP-7; MIP224
[Similar Products]
 NCBI Protein Information    26S protease regulatory subunit 6B; Tat-binding protein 7; protease 26S subunit 6; MB67-interacting protein; 26S proteasome AAA-ATPase subunit RPT3
 UniProt Protein Name    26S protease regulatory subunit 6B
 UniProt Synonym Protein Names   
26S proteasome AAA-ATPase subunit RPT3; MB67-interacting protein; MIP224; Proteasome 26S subunit ATPase 4; Tat-binding protein 7; TBP-7
 Protein Family    26S protease regulatory
 UniProt Gene Name    PSMC4 [Similar Products]
 UniProt Synonym Gene Names    MIP224; TBP7; TBP-7 [Similar Products]
 UniProt Entry Name    PRS6B_HUMAN
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 NCBI Summary for PSMC4    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the triple-A family of ATPases that is a component of the 19S regulatory subunit and plays a role in 26S proteasome assembly. The encoded protein interacts with gankyrin, a liver oncoprotein, and may also play a role in Parkinson's disease through interactions with synphilin-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for PSMC4    RPT3: an ATPase subunit of the 26S proteasome. A member of the triple-A family of ATPases which have a chaperone-like activity. Interacts with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Two splice variant isoforms have been described.

Protein type: Nuclear receptor co-regulator; Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 19q13.11-q13.13

Cellular Component: nucleoplasm; proteasome complex; membrane; cytoplasm; inclusion body; cytosol; nucleus

Molecular Function: protein binding; ATPase activity; ATP binding

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; blastocyst development; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; proteolysis; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis
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 Research Articles on PSMC4    1. Saquinavir-NO inhibits activation of S6 protein in androgen-dependent prostate cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PSMC4 elisa kitPathways associated with PSMC4 elisa kit
 Reference Product  PubMed Publications
 PSMC1 elisa kit  >3 publications with PSMC4 and PSMC1
 PSMD10 elisa kit  >2 publications with PSMC4 and PSMD10
 PSMC2 elisa kit  >2 publications with PSMC4 and PSMC2
 PSMC3 elisa kit  >2 publications with PSMC4 and PSMC3
 PSMB5 elisa kit  >1 publications with PSMC4 and PSMB5
 PSMD1 elisa kit  >1 publications with PSMC4 and PSMD1
 PSMC5 elisa kit  >1 publications with PSMC4 and PSMC5
 Products by Pathway  Pathway Diagram
 AMER1 Mutants Destabilize The Destruction Complex Pathway antibodies  AMER1 Mutants Destabilize The Destruction Complex Pathway Diagram
 APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway antibodies  APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway Diagram
 APC Truncation Mutants Have Impaired AXIN Binding Pathway antibodies  APC Truncation Mutants Have Impaired AXIN Binding Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 AXIN Missense Mutants Destabilize The Destruction Complex Pathway antibodies  AXIN Missense Mutants Destabilize The Destruction Complex Pathway Diagram
 AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway antibodies  AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway Diagram
Diseases associated with PSMC4 elisa kitOrgans/Tissues associated with PSMC4 elisa kit
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with PSMC4 and Nervous System Diseases
 Movement Disorders Antibodies  >4 publications with PSMC4 and Movement Disorders
 Brain Diseases Antibodies  >4 publications with PSMC4 and Brain Diseases
 Neoplasm Metastasis Antibodies  >1 publications with PSMC4 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >1 publications with PSMC4 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with PSMC4 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with PSMC4 and Brain
 Nerve Antibodies  >2 publications with PSMC4 and Nerve
 Blood Antibodies  >2 publications with PSMC4 and Blood
 Liver Antibodies  >2 publications with PSMC4 and Liver
 Lung Antibodies  >2 publications with PSMC4 and Lung
 Thyroid Antibodies  >1 publications with PSMC4 and Thyroid
 Muscle Antibodies  >1 publications with PSMC4 and Muscle
 Heart Antibodies  >1 publications with PSMC4 and Heart
 Prostate Antibodies  >1 publications with PSMC4 and Prostate
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