NP_034970.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
74,580 Da
NCBI Official Full Name
methylenetetrahydrofolate reductase isoform b
NCBI Official Synonym Full Names
5,10-methylenetetrahydrofolate reductase
NCBI Official Synonym Symbols
NCBI Protein Information
methylenetetrahydrofolate reductase
UniProt Protein Name
Methylenetetrahydrofolate reductase
UniProt Entry Name
MTHR_MOUSE
UniProt Comments for MTHFR
MTHFR: Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine. Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD). MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia, developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders. Defects in MTHFR may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (FS-NTD). The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Belongs to the methylenetetrahydrofolate reductase family.
Protein type: Cofactor and Vitamin Metabolism - one carbon pool by folate; Energy Metabolism - methane; EC 1.5.1.20; Oxidoreductase
Cellular Component: neuron projection; cytosol
Molecular Function: FAD binding; oxidoreductase activity; NADP binding; methylenetetrahydrofolate reductase (NADPH) activity; catalytic activity
Biological Process: tetrahydrofolate metabolic process; metabolic process; methionine biosynthetic process; methionine metabolic process; homocysteine metabolic process; one-carbon compound metabolic process
Research Articles on MTHFR
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with MTHFR elisa kit
Diseases associated with MTHFR elisa kit
Organs/Tissues associated with MTHFR elisa kit
|