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MTR elisa kit :: Mouse 5-methyltetrahydrofolate-homocysteine methyltransferase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9325332 MTR elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), ELISA Kit

★Popular Item★
 Also Known As   

Mouse Methionine synthase, MTR ELISA Kit

 Product Synonym Names    Mouse Methionine synthase (MTR) ELISA kit; FLJ33168; FLJ43216; FLJ45386; MS; cblG; 5-methyltetrahydrofolate-homocysteine methyltransferase 1; cobalamin-dependent methionine synthase; methionine synthase; vitamin-B12 dependent methionine synthas; 5-methyltetrahydrofolate-homocysteine methyltransferase
 Product Gene Name   

MTR elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for A6H5Y3
 Species Reactivity    Mouse
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    0.25 ng/ml - 8 ng/ml
 Sensitivity    0.1 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MTR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MTR purchase    MBS9325332 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25 ng/ml - 8 ng/ml in biological research samples containing MTR, with an estimated sensitivity of 0.1 ng/ml. The ELISA analytical biochemical technique of the MBS9325332 kit is based on MTR antibody-MTR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MTR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MTR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for MTR elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MTR (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9325332. Click to request current manual
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NCBI/Uniprot data below describe general gene information for MTR. It may not necessarily be applicable to this product.
 NCBI GI #    124487479
 NCBI GeneID    238505
 NCBI Accession #    NP_001074597.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001081128.3 [Other Products]
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 UniProt Primary Accession #    A6H5Y3 [Other Products]
 UniProt Secondary Accession #    Q3UQP2 [Other Products]
 UniProt Related Accession #    A6H5Y3 [Other Products]
 Molecular Weight    139,069 Da
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 NCBI Official Full Name    methionine synthase
 NCBI Official Synonym Full Names    5-methyltetrahydrofolate-homocysteine methyltransferase
 NCBI Official Symbol    Mtr [Similar Products]
 NCBI Official Synonym Symbols   
MS; AI894170; D830038K18Rik
[Similar Products]
 NCBI Protein Information    methionine synthase; vitamin-B12 dependent methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase
 UniProt Protein Name    Methionine synthase
 UniProt Synonym Protein Names   
5-methyltetrahydrofolate--homocysteine methyltransferase; Vitamin-B12 dependent methionine synthase; MS
 Protein Family    Mycothione reductase
 UniProt Gene Name    Mtr [Similar Products]
 UniProt Synonym Gene Names    MS [Similar Products]
 UniProt Entry Name    METH_MOUSE
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 UniProt Comments for MTR    MTR: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. Defects in MTR are the cause of methylcobalamin deficiency type G (cblG); also known as homocystinuria-megaloblastic anemia complementation type G. It is an autosomal recessive inherited disease that causes mental retardation, macrocytic anemia, and homocystinuria. Mild deficiency in MS activity could be associated with mild hyperhomocysteinemia, a risk factor for cardiovascular disease and possibly neural tube defects. MS mutations could also be involved in tumorigenesis. Defects in MTR may be a cause of susceptibility to folate-sensitive neural tube defects (FS-NTD). The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. Genetic defects in MTR may affect the risk of spina bifida via the maternal rather than the embryonic genotype. Belongs to the vitamin-B12 dependent methionine synthase family.

Protein type: Methyltransferase; Amino Acid Metabolism - cysteine and methionine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.1.13

Cellular Component: cytoplasm; intracellular; cytosol

Molecular Function: transferase activity; amino acid binding; methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding; metal ion binding; methionine synthase activity; cobalamin binding; folic acid binding

Biological Process: tetrahydrofolate metabolic process; methylation; cellular metabolic process; protein amino acid methylation; methionine biosynthetic process; pteridine and derivative metabolic process; methionine metabolic process; amino acid biosynthetic process; homocysteine metabolic process
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 Research Articles on MTR    1. Deficiency of either MS or folate produces oxidative stress and endothelial dysfunction in the cerebral microcirculation of mice.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MTR elisa kitDiseases associated with MTR elisa kit
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Folic Acid Network Pathway antibodies  Folic Acid Network Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Methylation Pathway antibodies  Methylation Pathway Diagram
 One Carbon Metabolism Pathway antibodies  One Carbon Metabolism Pathway Diagram
 One Carbon Metabolism And Related Pathways antibodies  One Carbon Metabolism And Related Pathways Diagram
 One Carbon Pool By Folate Pathway antibodies  One Carbon Pool By Folate Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >405 publications with MTR and Nervous System Diseases
 Demyelinating Diseases Antibodies  >223 publications with MTR and Demyelinating Diseases
 Neoplasms Antibodies  >189 publications with MTR and Neoplasms
 Brain Diseases Antibodies  >187 publications with MTR and Brain Diseases
 Gastrointestinal Diseases Antibodies  >45 publications with MTR and Gastrointestinal Diseases
 Neurologic Manifestations Antibodies  >34 publications with MTR and Neurologic Manifestations
 Cognition Disorders Antibodies  >34 publications with MTR and Cognition Disorders
 Skin Diseases Antibodies  >34 publications with MTR and Skin Diseases
 Dementia Antibodies  >34 publications with MTR and Dementia
 Edema Antibodies  >32 publications with MTR and Edema
Organs/Tissues associated with MTR elisa kit
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >434 publications with MTR and Brain
 Lung Antibodies  >27 publications with MTR and Lung
 Heart Antibodies  >26 publications with MTR and Heart
 Kidney Antibodies  >23 publications with MTR and Kidney
 Spleen Antibodies  >14 publications with MTR and Spleen
 Bone Marrow Antibodies  >12 publications with MTR and Bone Marrow
 Embryonic Tissue Antibodies  >11 publications with MTR and Embryonic Tissue
 Testis Antibodies  >10 publications with MTR and Testis
 Stomach Antibodies  >8 publications with MTR and Stomach
 Eye Antibodies  >7 publications with MTR and Eye
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