AAH96077.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
47,426 Da
NCBI Official Full Name
PFKFB1 protein
NCBI Official Synonym Full Names
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
NCBI Protein Information
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
UniProt Protein Name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
UniProt Synonym Protein Names
6PF-2-K/Fru-2,6-P2ase liver isozymeIncluding the following 2 domains:6-phosphofructo-2-kinase (EC:2.7.1.105)Fructose-2,6-bisphosphatase (EC:3.1.3.46)
UniProt Synonym Gene Names
NCBI Summary for PFKFB1
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for PFKFB1
Synthesis and degradation of fructose 2,6-bisphosphate.
Research Articles on PFKFB1
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Products associated with PFKFB1 elisa kit
Pathways associated with PFKFB1 elisa kit
Diseases associated with PFKFB1 elisa kit
Organs/Tissues associated with PFKFB1 elisa kit
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