AAH96077.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,681 Da
NCBI Official Full Name
PFKFB1 protein
NCBI Official Synonym Full Names
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
NCBI Protein Information
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; PFK/FBPase 1; 6PF-2-K/Fru-2,6-P2ase 1; 6PF-2-K/Fru-2,6-P2ASE liver isozyme; fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase
UniProt Protein Name
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1
UniProt Synonym Protein Names
6PF-2-K/Fru-2,6-P2ase liver isozyme
UniProt Synonym Gene Names
UniProt Entry Name
F261_HUMAN
NCBI Summary for PFKFB1
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for PFKFB1
PFKFB1: Synthesis and degradation of fructose 2,6-bisphosphate. Homodimer. Liver. Phosphorylation results in inhibition of the kinase activity.
Protein type: EC 2.7.1.105; Phosphatase (non-protein); Carbohydrate Metabolism - fructose and mannose; Kinase, other; EC 3.1.3.46; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xp11.21
Cellular Component: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex; cytosol
Molecular Function: identical protein binding; protein binding; fructose-2,6-bisphosphate 2-phosphatase activity; 6-phosphofructo-2-kinase activity; kinase binding; ATP binding
Biological Process: organ regeneration; response to glucagon stimulus; response to cAMP; glycolysis; response to glucocorticoid stimulus; glucose metabolic process; pathogenesis; fructose 2,6-bisphosphate metabolic process; gluconeogenesis; response to insulin stimulus; response to starvation; dephosphorylation; carbohydrate metabolic process; carbohydrate phosphorylation; energy reserve metabolic process; positive regulation of glucokinase activity; fructose metabolic process
Research Articles on PFKFB1
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Products associated with PFKFB1 elisa kit
Pathways associated with PFKFB1 elisa kit
Diseases associated with PFKFB1 elisa kit
Organs/Tissues associated with PFKFB1 elisa kit
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