AAS72298.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
68,256 Da
NCBI Official Full Name
ADAM15 isoform 8
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 15
NCBI Official Synonym Symbols
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 15; MDC-15; metalloprotease RGD disintegrin protein; a disintegrin and metalloproteinase domain 15 (metargidin); metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 15
UniProt Synonym Protein Names
Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; Metargidin
UniProt Synonym Gene Names
UniProt Entry Name
ADA15_HUMAN
NCBI Summary for ADAM15
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAM15
ADAM15: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. 11 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; Cell adhesion; EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cell projection; cell surface; adherens junction; acrosome; plasma membrane; integral to membrane
Molecular Function: integrin binding; protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; SH3 domain binding
Biological Process: integrin-mediated signaling pathway; collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; apoptosis; tissue regeneration; cell-matrix adhesion; innate immune response; negative regulation of cell growth; angiogenesis; proteolysis; negative regulation of cell-matrix adhesion; negative regulation of cell migration
Research Articles on ADAM15
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Products associated with ADAM15 elisa kit
Pathways associated with ADAM15 elisa kit
Diseases associated with ADAM15 elisa kit
Organs/Tissues associated with ADAM15 elisa kit
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