NP_033751.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
105,801 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
NCBI Official Synonym Symbols
C3-C5; METH1; ADAMTS; METH-1; ADAM-TS1; ADAMTS-1 [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 1
UniProt Synonym Gene Names
UniProt Entry Name
ATS1_MOUSE
NCBI Summary for Adamts1
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family and preproprotein that is proteolytically processed to generate a mature protein product. This secreted protein product plays an important role in ovulation, likely through its cleavage of the extracellular matrix component versican. The encoded protein may enhance tumorigenesis in a mouse model of breast cancer. Homozygous knockout mice for this gene exhibit enhanced perinatal lethality, impaired growth and adipose tissue development, and impaired ovulation in females. [provided by RefSeq, Oct 2015]
UniProt Comments for Adamts1
ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
Protein type: Secreted, signal peptide; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted
Cellular Component: basement membrane; cytoplasm; cytoplasmic vesicle; extracellular matrix; extracellular region; proteinaceous extracellular matrix
Molecular Function: heparin binding; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding
Biological Process: kidney development; negative regulation of angiogenesis; ovulation from ovarian follicle; proteolysis
Research Articles on Adamts1
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Products associated with Adamts1 elisa kit
Pathways associated with Adamts1 elisa kit
Diseases associated with Adamts1 elisa kit
Organs/Tissues associated with Adamts1 elisa kit
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