NP_653080.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
180,990 Da
NCBI Official Full Name
A-kinase anchor protein 12 isoform 2
NCBI Official Synonym Full Names
A kinase (PRKA) anchor protein 12
NCBI Protein Information
A-kinase anchor protein 12; AKAP 250; kinase scaffold protein gravin; A-kinase anchor protein, 250kDa; Src-Suppressed C Kinase Substrate; myasthenia gravis autoantigen gravin
UniProt Protein Name
A-kinase anchor protein 12
UniProt Synonym Protein Names
A-kinase anchor protein 250 kDa; AKAP 250; Gravin; Myasthenia gravis autoantigen
UniProt Synonym Gene Names
UniProt Entry Name
AKA12_HUMAN
NCBI Summary for AKAP12
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for AKAP12
AKAP12: a scaffold protein that contains 3 conserved PKA binding motifs. Suppresses podosome formation, inhibits RhoA and Cdc42 activity, and inhibits v-Src-induced oncogenic growth in NIH3T3. May inhibit Src-induced oncogenesis by reestablishing actin-based non-invasive cytoskeletal architecture.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 6q24-q25
Cellular Component: cytoskeleton; focal adhesion; cytoplasm; plasma membrane; cell cortex
Molecular Function: protein binding; protein kinase A binding; adenylate cyclase binding
Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of cAMP biosynthetic process; protein targeting
Research Articles on AKAP12
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Products associated with AKAP12 elisa kit
Pathways associated with AKAP12 elisa kit
Diseases associated with AKAP12 elisa kit
Organs/Tissues associated with AKAP12 elisa kit
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