Q8R0I0.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
40,340 Da
NCBI Official Full Name
Angiotensin-converting enzyme 2
NCBI Official Synonym Full Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
NCBI Protein Information
angiotensin-converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme 2
UniProt Protein Name
Angiotensin-converting enzyme 2
UniProt Synonym Protein Names
ACE-related carboxypeptidaseCleaved into the following chain:Processed angiotensin-converting enzyme 2
UniProt Entry Name
ACE2_MOUSE
UniProt Comments for ACE2
ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.17.23; Protease; Membrane protein, integral
Cellular Component: extracellular space; cell surface; membrane; cytoplasm; integral to membrane; extracellular region; plasma membrane
Molecular Function: viral receptor activity; peptidase activity; peptidyl-dipeptidase activity; hydrolase activity; metallopeptidase activity; carboxypeptidase activity; metal ion binding; endopeptidase activity; glycoprotein binding
Biological Process: virion attachment, binding of host cell surface receptor; negative regulation of smooth muscle cell proliferation; receptor biosynthetic process; proteolysis; angiotensin mediated drinking behavior; regulation of systemic arterial blood pressure by renin-angiotensin
Research Articles on ACE2
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Pathways associated with ACE2 elisa kit
Diseases associated with ACE2 elisa kit
Organs/Tissues associated with ACE2 elisa kit
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