NP_054720.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,148 Da
NCBI Official Full Name
ADP-ribosylation factor-binding protein GGA3 isoform short
NCBI Official Synonym Full Names
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
NCBI Protein Information
ADP-ribosylation factor-binding protein GGA3; Golgi-localized, gamma ear-containing, ARF-binding protein 3
UniProt Protein Name
ADP-ribosylation factor-binding protein GGA3
UniProt Synonym Protein Names
Golgi-localized, gamma ear-containing, ARF-binding protein 3
UniProt Synonym Gene Names
UniProt Entry Name
GGA3_HUMAN
NCBI Summary for GGA3
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]
UniProt Comments for GGA3
GGA3: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif. Monomer. Interacts with SORT1, SORL1, LRP3, GGA binding partner (GGABP) and P200. Interacts with GGA1 and GGA2. Binds to clathrin and activated ARFs. Binds RABEP1 and RABGEF1. Interacts with the membrane proteins M6PR/CD-MPR, IGF2R/CI-MPR and BACE1 and the accessory proteins SYNRG, EPN4, NECAP1, NECAP2 and AFTPH/aftiphilin. Interacts with TSG101 and UBC. Ubiquitously expressed. Belongs to the GGA protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: clathrin adaptor complex; endosome membrane; trans-Golgi network
Molecular Function: ADP-ribosylation factor binding; protein binding
Biological Process: vesicle-mediated transport; intracellular protein transport; positive regulation of protein catabolic process
Research Articles on GGA3
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Products associated with GGA3 elisa kit
Pathways associated with GGA3 elisa kit
Diseases associated with GGA3 elisa kit
Organs/Tissues associated with GGA3 elisa kit
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