Q9R182.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
52,543 Da
NCBI Official Full Name
Angiopoietin-related protein 3
NCBI Official Synonym Full Names
angiopoietin-like 3
NCBI Official Synonym Symbols
NCBI Protein Information
angiopoietin-related protein 3; hypolipidemia; angiopoietin-like protein 3
UniProt Protein Name
Angiopoietin-related protein 3
UniProt Synonym Protein Names
Angiopoietin-like protein 3
UniProt Entry Name
ANGL3_MOUSE
NCBI Summary for ANGPTL3
This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015]
UniProt Comments for ANGPTL3
ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.
Protein type: Cell adhesion; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Inhibitor
Cellular Component: Golgi apparatus; extracellular space; cell surface; early endosome; extracellular region
Molecular Function: integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity
Biological Process: cholesterol metabolic process; phospholipid catabolic process; glycerol metabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; positive regulation of angiogenesis; sequestering of lipid; cholesterol homeostasis; triacylglycerol metabolic process; acylglycerol homeostasis; phospholipid metabolic process; negative regulation of catalytic activity; artery morphogenesis; positive regulation of lipid metabolic process; negative regulation of lipoprotein lipase activity; positive regulation of cell migration; phospholipid homeostasis
Research Articles on ANGPTL3
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Pathways associated with ANGPTL3 elisa kit
Diseases associated with ANGPTL3 elisa kit
Organs/Tissues associated with ANGPTL3 elisa kit
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