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ATM elisa kit :: Mouse ATM ELISA Kit

Scan QR to view Datasheet Catalog #    MBS2501227
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $410 +1 FREE 8GB USB
96-Strip-Wells  /  $490 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,040 +2 FREE 8GB USB
10x96-Strip-Wells  /  $3,590 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATM, ELISA Kit

★Popular Item★
 Also Known As   

Mouse ATM (Ataxia Telangiectasia Mutated) ELISA Kit

 Product Gene Name   

ATM elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    208900
 3D Structure    ModBase 3D Structure for Q13315
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 Species Reactivity    Mouse
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Mouse ATM. No significant cross-reactivity or interference between Mouse ATM and analogues was observed. Note: Limited by current skills and knowledge, it is impossible for us to complete the cross- reactivity detection between Mouse ATM and all the analogues, therefore, cross reaction may still exist.
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 Samples    Serum, Plasma, Biological Fluids
 Assay Type    Sandwich
 Detection Range    7.813--500pg/mL
 Sensitivity    4.688pg/mL
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 Preparation and Storage    Store at 4 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ATM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ATM purchase    MBS2501227 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATM, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 7.813--500pg/mL in biological research samples containing ATM, with an estimated sensitivity of 4.688pg/mL. The ELISA analytical biochemical technique of the MBS2501227 kit is based on ATM antibody-ATM antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ATM antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ATM. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, Plasma, Biological Fluids. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ATM elisa kit

   Description: The kit is a sandwich enzyme immunoassay for in vitro quantitative measurement of ATM in Mouse serum, plasma and other biological fluids
Principle of the Assay: This ELISA kit uses Sandwich-ELISA as the method. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse ATM. Standards or samples are added to the appropriate micro ELISA plate wells and bound by the specific antibody. Then a biotinylated detection antibody specific for Mouse ATM and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse ATM, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The OD value is proportional to the concentration of Mouse ATM. You can calculate the concentration of Mouse ATM in the samples by comparing the OD of the samples to the standard curve.
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 Typical Testing Data/Standard Curve (for reference only) of ATM elisa kit    ATM elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS2501227. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ATM. It may not necessarily be applicable to this product.
 NCBI GI #    2304971
 NCBI GeneID    472
 NCBI Accession #    AAB65827.1 [Other Products]
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 UniProt Primary Accession #    Q13315 [Other Products]
 UniProt Secondary Accession #    O15429; Q12758; Q16551; Q93007; Q9NP02; Q9UCX7; B2RNX5 [Other Products]
 UniProt Related Accession #    Q13315 [Other Products]
 Molecular Weight    350,687 Da
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 NCBI Official Full Name    ATM
 NCBI Official Synonym Full Names    ATM serine/threonine kinase
 NCBI Official Symbol    ATM [Similar Products]
 NCBI Official Synonym Symbols   
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
[Similar Products]
 NCBI Protein Information    serine-protein kinase ATM; A-T mutated; AT mutated; TEL1, telomere maintenance 1, homolog; ataxia telangiectasia mutated
 UniProt Protein Name    Serine-protein kinase ATM
 UniProt Synonym Protein Names   
Ataxia telangiectasia mutated; A-T mutated
 Protein Family    ATM interactor
 UniProt Gene Name    ATM [Similar Products]
 UniProt Synonym Gene Names    A-T mutated [Similar Products]
 UniProt Entry Name    ATM_HUMAN
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 NCBI Summary for ATM    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
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 UniProt Comments for ATM    ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); DNA repair, damage; Tumor suppressor; Protein kinase, atypical; EC 2.7.11.1; ATYPICAL group; PIKK family

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasmic membrane-bound vesicle; spindle

Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; 1-phosphatidylinositol-3-kinase activity; protein complex binding; DNA-dependent protein kinase activity; protein N-terminus binding; histone serine kinase activity; ATP binding

Biological Process: lipoprotein catabolic process; DNA damage induced protein phosphorylation; positive regulation of apoptosis; heart development; protein amino acid autophosphorylation; pre-B cell allelic exclusion; negative regulation of B cell proliferation; signal transduction; protein amino acid phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; double-strand break repair; positive regulation of neuron apoptosis; mitotic cell cycle spindle assembly checkpoint; cell cycle arrest; telomere maintenance; somitogenesis; V(D)J recombination; DNA repair; double-strand break repair via homologous recombination; neuron apoptosis; peptidyl-serine phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; meiotic recombination; response to hypoxia; brain development; positive regulation of DNA damage response, signal transduction by p53 class mediator; response to ionizing radiation; response to DNA damage stimulus; oocyte development

Disease: Breast Cancer; Ataxia-telangiectasia
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 Research Articles on ATM    1. Huntington's disease cells presented a delayed nucleo-shuttling of phosphorylated forms of the ATM kinase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ATM elisa kitPathways associated with ATM elisa kit
 Reference Product  PubMed Publications
 BRCA1 elisa kit  >553 publications with ATM and BRCA1
 CHEK2 elisa kit  >472 publications with ATM and CHEK2
 TP53 elisa kit  >388 publications with ATM and TP53
 H2AFX elisa kit  >363 publications with ATM and H2AFX
 MRE11A elisa kit  >187 publications with ATM and MRE11A
 TP53BP1 elisa kit  >112 publications with ATM and TP53BP1
 RAD17 elisa kit  >63 publications with ATM and RAD17
 KAT5 elisa kit  >23 publications with ATM and KAT5
 ABL1 elisa kit  >4 publications with ATM and ABL1
 Products by Pathway  Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway antibodies  Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 BRCA1-associated Genome Surveillance Complex (BASC) Pathway antibodies  BRCA1-associated Genome Surveillance Complex (BASC) Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with ATM elisa kitOrgans/Tissues associated with ATM elisa kit
 Disease Name  Pubmed Publications
 Ataxia Telangiectasia Antibodies  >4233 publications with ATM and Ataxia Telangiectasia
 Nervous System Diseases Antibodies  >1510 publications with ATM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1298 publications with ATM and Cardiovascular Diseases
 Brain Diseases Antibodies  >1292 publications with ATM and Brain Diseases
 Breast Neoplasms Antibodies  >475 publications with ATM and Breast Neoplasms
 Disease Models, Animal Antibodies  >307 publications with ATM and Disease Models, Animal
 Heart Diseases Antibodies  >299 publications with ATM and Heart Diseases
 Lung Diseases Antibodies  >232 publications with ATM and Lung Diseases
 Inflammation Antibodies  >207 publications with ATM and Inflammation
 Adenocarcinoma Antibodies  >192 publications with ATM and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1374 publications with ATM and Blood
 Brain Antibodies  >765 publications with ATM and Brain
 Lung Antibodies  >532 publications with ATM and Lung
 Vascular Antibodies  >515 publications with ATM and Vascular
 Heart Antibodies  >314 publications with ATM and Heart
 Muscle Antibodies  >246 publications with ATM and Muscle
 Liver Antibodies  >204 publications with ATM and Liver
 Skin Antibodies  >202 publications with ATM and Skin
 Kidney Antibodies  >174 publications with ATM and Kidney
 Nerve Antibodies  >165 publications with ATM and Nerve
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