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ABCA4 elisa kit :: Mouse ATP-binding cassette, sub-family A (ABC1) , member 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9322333 ABCA4 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATP-binding cassette, sub-family A (ABC1) , member 4 (ABCA4), ELISA Kit

 Also Known As   

Mouse Retinal-specific ATP-binding cassette transporter, ABCA4 ELISA Kit

 Product Synonym Names    Mouse Retinal-specific ATP-binding cassette transporter (ABCA4) ELISA kit; ABC10; ABCR; ARMD2; CORD3; DKFZp781N1972; FFM; FLJ17534; RMP; RP19; STGD; STGD1; ATP binding cassette transporter; ATP-binding cassette; sub-family A member 4; ATP-binding transporter; retina-specific; ATP-binding cassette; sub-family A (ABC1); member 4
 Product Gene Name   

ABCA4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 3D Structure    ModBase 3D Structure for O35600
 Species Reactivity    Mouse
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ABCA4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ABCA4 purchase    MBS9322333 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ATP-binding cassette, sub-family A (ABC1), member 4 (ABCA4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ABCA4. The ELISA analytical biochemical technique of the MBS9322333 kit is based on ABCA4 antibody-ABCA4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ABCA4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ABCA4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ABCA4. It may not necessarily be applicable to this product.
 NCBI GI #    6671495
 NCBI GeneID    11304
 NCBI Accession #    NP_031404.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007378.1 [Other Products]
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 UniProt Primary Accession #    O35600 [Other Products]
 UniProt Related Accession #    O35600 [Other Products]
 Molecular Weight    260,209 Da
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 NCBI Official Full Name    retinal-specific ATP-binding cassette transporter
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family A (ABC1), member 4
 NCBI Official Symbol    Abca4 [Similar Products]
 NCBI Official Synonym Symbols   
RmP; Abcr; Abc10; AW050280; D430003I15Rik
[Similar Products]
 NCBI Protein Information    retinal-specific ATP-binding cassette transporter; Rim protein; RIM ABC transporter; ATP-binding cassette 10; ATP-binding cassette sub-family A member 4
 UniProt Protein Name    Retinal-specific ATP-binding cassette transporter
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP
 Protein Family    ABC transporter A family
 UniProt Gene Name    Abca4 [Similar Products]
 UniProt Synonym Gene Names    Abcr; RIM protein; RmP [Similar Products]
 UniProt Entry Name    ABCA4_MOUSE
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 NCBI Summary for ABCA4    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein was the first of the ABC transporters to be observed in photoreceptors and may play a role in the photoresponse. Mutations in the human gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and macular degeneration age-related 2. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA4    ABCA4: In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic surface, ATR is reduced to vitamin A by trans- retinol dehydrogenase (tRDH) and then transferred to the retinal pigment epithelium (RPE) where it is converted to 11-cis-retinal. May play a role in photoresponse, removing ATR/NR-PE from the extracellular photoreceptor surfaces during bleach recovery. Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD1 inheritance is autosomal recessive. Defects in ABCA4 are the cause of fundus flavimaculatus (FFM). FFM is an autosomal recessive retinal disorder very similar to Stargardt disease. In contrast to Stargardt disease, FFM is characterized by later onset and slowly progressive course. Defects in ABCA4 may be a cause of age-related macular degeneration type 2 (ARMD2). ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Defects in ABCA4 are the cause of cone-rod dystrophy type 3 (CORD3). CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. Defects in ABCA4 are the cause of retinitis pigmentosa type 19 (RP19). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP19 is characterized by choroidal atrophy. Inheritance is autosomal recessive. Belongs to the ABC transporter superfamily. ABCA family.

Protein type: Membrane protein, integral; Transporter, ABC family; Transporter; Membrane protein, multi-pass

Cellular Component: photoreceptor outer segment; intracellular membrane-bound organelle; membrane; integral to plasma membrane; integral to membrane

Molecular Function: phospholipid-translocating ATPase activity; phospholipid transporter activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity; cholesterol transporter activity; ATPase activity; nucleotide binding; ATP binding

Biological Process: phospholipid translocation; phospholipid transfer to membrane; phospholipid efflux; visual perception; transport; photoreceptor cell maintenance; response to stimulus; cholesterol efflux; transmembrane transport
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 Research Articles on ABCA4    1. Despite pronounced lipofuscin accumulation in the retinal pigment epithelium of Abca4(-/-) mice, ERG and histology showed a slow age-related thinning of the photoreceptor layer similar to wild type controls up to 12 months.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCA4 elisa kitDiseases associated with ABCA4 elisa kit
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway antibodies  The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram
 Disease Name  Pubmed Publications
 Macular Degeneration Antibodies  >248 publications with ABCA4 and Macular Degeneration
 Retinitis Pigmentosa Antibodies  >86 publications with ABCA4 and Retinitis Pigmentosa
 Macular Degeneration, Age-Related, 2 Antibodies  >82 publications with ABCA4 and Macular Degeneration, Age-Related, 2
 Stargardt disease 1 Antibodies  >38 publications with ABCA4 and Stargardt disease 1
 Cone-Rod Dystrophy 3 Antibodies  >31 publications with ABCA4 and Cone-Rod Dystrophy 3
 Disease Models, Animal Antibodies  >27 publications with ABCA4 and Disease Models, Animal
 Cleft Lip Antibodies  >12 publications with ABCA4 and Cleft Lip
 Anemia Antibodies  >3 publications with ABCA4 and Anemia
 Polyneuropathies Antibodies  >3 publications with ABCA4 and Polyneuropathies
 Muscular Diseases Antibodies  >2 publications with ABCA4 and Muscular Diseases
Organs/Tissues associated with ABCA4 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >204 publications with ABCA4 and Eye
 Liver Antibodies  >5 publications with ABCA4 and Liver
 Lung Antibodies  >4 publications with ABCA4 and Lung
 Kidney Antibodies  >3 publications with ABCA4 and Kidney
 Ovary Antibodies  >2 publications with ABCA4 and Ovary
 Embryonic Tissue Antibodies  >1 publications with ABCA4 and Embryonic Tissue
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