XP_006512862.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,650 Da
NCBI Official Full Name
jouberin isoform X2
NCBI Official Synonym Full Names
Abelson helper integration site 1
NCBI Official Synonym Symbols
Ahi-1; D10Bwg0629e; 1700015F03Rik [Similar Products]
NCBI Protein Information
jouberin; abelson helper integration site 1 protein
UniProt Protein Name
Jouberin
UniProt Synonym Protein Names
Abelson helper integration site 1 protein; AHI-1
UniProt Synonym Gene Names
UniProt Entry Name
AHI1_MOUSE
UniProt Comments for AHI1
AHI1: is up-regulated at all stages of chronic myeloid leukemia (CML). Down-regulated during early differentiation of normal hematopoietic cells. The AHI-1 gene is activated by insertional mutagenesis in mouse models of leukemia. Important for cerebellar and cortical development, and axonal decussation. Mutations of the AHI-1 gene are associated with Joubert syndrome. Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Genetic analysis indicates that it is important in the development of human-specific motor behaviors. Three alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold
Cellular Component: centriole; centrosome; adherens junction; cytoskeleton; photoreceptor outer segment; cell projection; nonmotile primary cilium; cytoplasm; intercellular junction; cell junction; cilium
Molecular Function: identical protein binding; protein binding
Biological Process: positive regulation of polarized epithelial cell differentiation; central nervous system development; vesicle targeting; positive regulation of receptor internalization; specification of axis polarity; vesicle-mediated transport; cell projection organization and biogenesis; retina development in camera-type eye; protein localization in organelle; cilium biogenesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; transmembrane receptor protein tyrosine kinase signaling pathway; morphogenesis of a polarized epithelium; negative regulation of apoptosis; regulation of behavior; hindbrain development
Research Articles on AHI1
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Products associated with AHI1 elisa kit
Pathways associated with AHI1 elisa kit
Organs/Tissues associated with AHI1 elisa kit
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