NP_001070020.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,087 Da
NCBI Official Full Name
acetyl-coenzyme A synthetase, cytoplasmic isoform 2
NCBI Official Synonym Full Names
acyl-CoA synthetase short-chain family member 2
NCBI Official Synonym Symbols
ACS; ACSA; ACAS2; ACECS; dJ1161H23.1 [Similar Products]
NCBI Protein Information
acetyl-coenzyme A synthetase, cytoplasmic; acetate thiokinase; acetate-CoA ligase; acyl-activating enzyme; cytoplasmic acetyl-coenzyme A synthetase; acetyl-Coenzyme A synthetase 2 (ADP forming)
UniProt Protein Name
Acetyl-coenzyme A synthetase, cytoplasmic
UniProt Synonym Protein Names
Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme
UniProt Synonym Gene Names
UniProt Entry Name
ACSA_HUMAN
NCBI Summary for ACSS2
This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
UniProt Comments for ACSS2
ACSS2: Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Ligase
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; cytosol
Molecular Function: acetate-CoA ligase activity; ATP binding; AMP binding
Biological Process: acetyl-CoA biosynthetic process from acetate; xenobiotic metabolic process; lipid biosynthetic process; propionate biosynthetic process; ethanol oxidation; acetate biosynthetic process
Research Articles on ACSS2
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Products associated with ACSS2 elisa kit
Pathways associated with ACSS2 elisa kit
Diseases associated with ACSS2 elisa kit
Organs/Tissues associated with ACSS2 elisa kit
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