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ASM elisa kit :: Mouse Acid Sphingomyelinase ELISA Kit

Scan QR to view Datasheet Catalog #    MBS006247 ASM elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Acid Sphingomyelinase (ASM), ELISA Kit

 Also Known As   

Mouse Acid Sphingomyelinase ELISA Kit

 Product Gene Name   

ASM elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 Chromosome Location    Chromosome: 11; NC_000011.9 (6411644..6416228). Location: 11p15.4-p15.1
 OMIM    257200
 3D Structure    ModBase 3D Structure for P17405
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 Species Reactivity    Mouse
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 Assay Type    Sandwich
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ASM elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ASM purchase    MBS006247 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Acid Sphingomyelinase (ASM) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ASM. The ELISA analytical biochemical technique of the MBS006247 kit is based on ASM antibody-ASM antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ASM antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ASM. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for ASM. It may not necessarily be applicable to this product.
 NCBI GI #    179095
 NCBI GeneID    6609
 NCBI Accession #    AAA58377.1 [Other Products]
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 UniProt Primary Accession #    P17405 [Other Products]
 UniProt Secondary Accession #    P17406; Q13811; Q16837; Q16841; A8K8M3; E9PKS3 [Other Products]
 UniProt Related Accession #    P17405 [Other Products]
 Molecular Weight    69,752 Da
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 NCBI Official Full Name    acid sphingomyelinase
 NCBI Official Synonym Full Names    sphingomyelin phosphodiesterase 1, acid lysosomal
 NCBI Official Symbol    SMPD1 [Similar Products]
 NCBI Official Synonym Symbols   
ASM; NPD; ASMASE
[Similar Products]
 NCBI Protein Information    sphingomyelin phosphodiesterase; acid sphingomyelinase
 UniProt Protein Name    Sphingomyelin phosphodiesterase
 UniProt Synonym Protein Names   
Acid sphingomyelinase
 Protein Family    Acid sphingomyelinase-like phosphodiesterase
 UniProt Gene Name    SMPD1 [Similar Products]
 UniProt Synonym Gene Names    ASM; aSMase [Similar Products]
 UniProt Entry Name    ASM_HUMAN
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 NCBI Summary for ASM    The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]
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 UniProt Comments for ASM    SMPD1: Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity. Monomer. Belongs to the acid sphingomyelinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - sphingolipid; EC 3.1.4.12; Phosphodiesterase

Chromosomal Location of Human Ortholog: 11p15.4-p15.1

Cellular Component: extracellular space; lysosomal lumen; lysosome; plasma membrane; endosome; lamellar body

Molecular Function: protein binding; sphingomyelin phosphodiesterase activity; hydrolase activity, acting on glycosyl bonds

Biological Process: response to drug; negative regulation of MAP kinase activity; nervous system development; sphingomyelin metabolic process; sphingolipid metabolic process; positive regulation of apoptosis; ceramide biosynthetic process; glycosphingolipid metabolic process; sphingomyelin catabolic process; response to cocaine; signal transduction; positive regulation of protein amino acid dephosphorylation

Disease: Niemann-pick Disease, Type B; Niemann-pick Disease, Type A
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 Research Articles on ASM    1. Chinese population may have a comparably high incidence of sphingomyelinase-deficient Niemann-Pick disease type A. This study has identified some novel genotype and phenotype correlations in this rare and devastating disorder
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ASM elisa kitPathways associated with ASM elisa kit
 Reference Product  PubMed Publications
 GBA elisa kit  >1 publications with ASM and GBA
 SMPD2 elisa kit  >1 publications with ASM and SMPD2
 Products by Pathway  Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 FAS (CD95) Signaling Pathway antibodies  FAS (CD95) Signaling Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 IL2 Signaling Events Mediated By PI3K Pathway antibodies  IL2 Signaling Events Mediated By PI3K Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Ovarian Infertility Genes Pathway antibodies  Ovarian Infertility Genes Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
Diseases associated with ASM elisa kitOrgans/Tissues associated with ASM elisa kit
 Disease Name  Pubmed Publications
 Niemann-Pick Diseases Antibodies  >29 publications with ASM and Niemann-Pick Diseases
 Niemann-Pick Disease, Type B Antibodies  >9 publications with ASM and Niemann-Pick Disease, Type B
 Neoplasms Antibodies  >4 publications with ASM and Neoplasms
 Inflammation Antibodies  >4 publications with ASM and Inflammation
 Disease Models, Animal Antibodies  >3 publications with ASM and Disease Models, Animal
 Niemann-Pick Disease, Type A Antibodies  >3 publications with ASM and Niemann-Pick Disease, Type A
 Necrosis Antibodies  >2 publications with ASM and Necrosis
 Liver Diseases Antibodies  >1 publications with ASM and Liver Diseases
 Hepatomegaly Antibodies  >1 publications with ASM and Hepatomegaly
 Fibrosis Antibodies  >1 publications with ASM and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with ASM and Blood
 Brain Antibodies  >9 publications with ASM and Brain
 Liver Antibodies  >6 publications with ASM and Liver
 Skin Antibodies  >5 publications with ASM and Skin
 Bone Antibodies  >5 publications with ASM and Bone
 Vascular Antibodies  >3 publications with ASM and Vascular
 Lung Antibodies  >3 publications with ASM and Lung
 Adipose Tissue Antibodies  >2 publications with ASM and Adipose Tissue
 Nerve Antibodies  >2 publications with ASM and Nerve
 Connective Tissue Antibodies  >2 publications with ASM and Connective Tissue
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