NP_001186883.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,793 Da
NCBI Official Full Name
actin, cytoplasmic 2
NCBI Official Synonym Full Names
actin, gamma 1
NCBI Official Synonym Symbols
ACT; ACTG; BRWS2; DFNA20; DFNA26; HEL-176 [Similar Products]
NCBI Protein Information
actin, cytoplasmic 2; cytoskeletal gamma-actin; epididymis luminal protein 176
UniProt Protein Name
Actin, cytoplasmic 2
UniProt Synonym Protein Names
Gamma-actinCleaved into the following chain:Actin, cytoplasmic 2, N-terminally processed
UniProt Synonym Gene Names
UniProt Entry Name
ACTG_HUMAN
NCBI Summary for ACTg1
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
UniProt Comments for ACTg1
ACTG1: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Belongs to the actin family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 17q25
Cellular Component: filamentous actin; extracellular space; cytoskeleton; myofibril; membrane; plasma membrane; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; ubiquitin protein ligase binding; ATP binding
Biological Process: intercellular junction assembly and maintenance; retinal homeostasis; axon guidance; ephrin receptor signaling pathway; innate immune response; sarcomere organization; cell motility; vascular endothelial growth factor receptor signaling pathway
Disease: Baraitser-winter Syndrome 2; Deafness, Autosomal Dominant 20
Research Articles on ACTg1
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Products associated with ACTg1 elisa kit
Pathways associated with ACTg1 elisa kit
Diseases associated with ACTg1 elisa kit
Organs/Tissues associated with ACTg1 elisa kit
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