NP_001106.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
140,122 Da
NCBI Official Full Name
adenylate cyclase type 8
NCBI Official Synonym Full Names
adenylate cyclase 8 (brain)
NCBI Protein Information
adenylate cyclase type 8; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase
UniProt Protein Name
Adenylate cyclase type 8
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase
UniProt Synonym Gene Names
UniProt Entry Name
ADCY8_HUMAN
NCBI Summary for ADCY8
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
UniProt Comments for ADCY8
ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; EC 4.6.1.1; Lyase; Transporter, aquaporin family; Adenylyl cyclase
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: membrane; plasma membrane; integral to membrane
Molecular Function: metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport
Research Articles on ADCY8
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Products associated with ADCY8 elisa kit
Pathways associated with ADCY8 elisa kit
Diseases associated with ADCY8 elisa kit
Organs/Tissues associated with ADCY8 elisa kit
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