NP_001623.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,954 Da
NCBI Official Full Name
alkaline phosphatase, placental type preproprotein
NCBI Official Synonym Full Names
alkaline phosphatase, placental
NCBI Protein Information
alkaline phosphatase, placental type; Regan isozyme; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme
UniProt Protein Name
Alkaline phosphatase, placental type
UniProt Synonym Protein Names
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1
UniProt Synonym Gene Names
UniProt Entry Name
PPB1_HUMAN
NCBI Summary for ALPL
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for ALPL
ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]
Protein type: Cell surface; Membrane protein, integral; EC 3.1.3.1; Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - folate biosynthesis; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 2q37
Cellular Component: cell surface; plasma membrane; integral to membrane
Molecular Function: zinc ion binding; alkaline phosphatase activity; magnesium ion binding
Biological Process: dephosphorylation
Research Articles on ALPL
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Products associated with ALPL elisa kit
Pathways associated with ALPL elisa kit
Diseases associated with ALPL elisa kit
Organs/Tissues associated with ALPL elisa kit
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