Q61838.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
165,853 Da
NCBI Official Full Name
Pregnancy zone protein
UniProt Protein Name
Pregnancy zone protein
UniProt Synonym Protein Names
Alpha-2-macroglobulin; Alpha-2-M
UniProt Synonym Gene Names
UniProt Entry Name
PZP_MOUSE
UniProt Comments for A2m
PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Cellular Component: extracellular region; extracellular space
Molecular Function: brain-derived neurotrophic factor binding; endopeptidase inhibitor activity; nerve growth factor binding; protease inhibitor activity; protein complex binding; serine-type endopeptidase inhibitor activity
Biological Process: embryo implantation; negative regulation of peptidase activity
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Products associated with A2m elisa kit
Diseases associated with A2m elisa kit
Organs/Tissues associated with A2m elisa kit
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