NP_036948.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,828 Da
NCBI Official Full Name
alpha-methylacyl-CoA racemase
NCBI Official Synonym Full Names
alpha-methylacyl-CoA racemase
NCBI Official Synonym Symbols
NCBI Protein Information
alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase; 2-arylpropionyl-CoA epimerase
UniProt Protein Name
Alpha-methylacyl-CoA racemase
UniProt Synonym Protein Names
2-arylpropionyl-CoA epimerase; 2-methylacyl-CoA racemase
UniProt Entry Name
AMACR_RAT
NCBI Summary for AMACR
enzmyme that converts pristanoyl-CoA and C27-bile acyl-CoAs to (S)-stereoisomers; involved in the degradation of the side chain of bile acid intermediates [RGD, Feb 2006]
UniProt Comments for AMACR
AMACR: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers. Has a role in drug metabolism as well as probably in lipid metabolism. The 2-arylpropionic acid (2-APA's) derivatives, including ibuprofen, are the most widely used anti-inflammatory analgesic cyclooxygenase inhibitors. The (-)-R-enantiomer, which is inactive in terms of cyclooxygenase inhibition, is epimerized in vivo via this enzyme to the cyclooxygenase-inhibiting (+)-S-enantiomer
Protein type: EC 5.1.99.4; Lipid Metabolism - primary bile acid biosynthesis; Isomerase; Mitochondrial
Cellular Component: mitochondrion; cytoplasm; peroxisome
Molecular Function: catalytic activity; alpha-methylacyl-CoA racemase activity; receptor binding
Biological Process: bile acid biosynthetic process; metabolic process; bile acid metabolic process; fatty acid metabolic process
Research Articles on AMACR
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Pathways associated with AMACR elisa kit
Organs/Tissues associated with AMACR elisa kit
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