NP_001029340.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,089 Da
NCBI Official Full Name
ankyrin-2 isoform 3
NCBI Official Synonym Full Names
ankyrin 2, brain
NCBI Official Synonym Symbols
Ank-2; Gm4392; AI835472; AW491075; 100043364 [Similar Products]
NCBI Protein Information
ankyrin-2
UniProt Protein Name
Ankyrin-2
UniProt Synonym Protein Names
Ankyrin-B
UniProt Synonym Gene Names
UniProt Comments for ANK2
Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors (PubMed:19007774). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:15262991). In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (PubMed:19109891). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357).
Research Articles on ANK2
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Diseases associated with ANK2 elisa kit
Organs/Tissues associated with ANK2 elisa kit
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